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Article
Mesothelin-specific cell-based vaccine generates antigen-specific immunity and potent antitumor effects by combining with IL-12 immunomodulator
Ovarian cancer is a gynecologic malignancy with a high mortality rate. In the present study, we developed a novel cell-based vaccine, Meso-VAX, to generate mesothelin antigen-specific immune responses and immu...
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Article
High-frequency PIN–PMN–PT single crystal ultrasonic transducer for imaging applications
A high-frequency (∼60 MHz) ultrasonic transducer with a [001]-oriented 0.27Pb(In1/2Nb1/2)O3–0.45Pb(Mg1/3Nb2/3)O3–0.28PbTiO3 (PIN–PMN–PT) piezoelectric single crystal as an active element has been fabricated and c...
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Article
Noncarrier naked antigen-specific DNA vaccine generates potent antigen-specific immunologic responses and antitumor effects
Genetic immunization strategies have largely focused on the use of plasmid DNA with a gene gun. However, there remains a clear need to further improve the efficiency, safety, and cost of potential DNA vaccines...
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Article
Open AccessHigh mesothelin correlates with chemoresistance and poor survival in epithelial ovarian carcinoma
The objective of this paper is to investigate the mesothelin expression level to the clinicopathological features, chemoresponse, and to the outcome of patients with epithelial ovarian carcinoma (EOC). Mesothe...
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Article
Connective tissue growth factor linked to the E7 tumor antigen generates potent antitumor immune responses mediated by an antiapoptotic mechanism
A novel method for generating an antigen-specific cancer vaccine and immunotherapy has emerged using a DNA vaccine. However, antigen-presenting cells (APCs) have a limited life span, which hinders their long-t...
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Article
Open AccessHuman papillomaviral load changes in low-grade squamous intraepithelial lesions of the uterine cervix
To better predict risk of progression of low-grade squamous intraepithelial lesions (LSILs) of the uterine cervix in women with human papillomavirus (HPV) infections, 294 baseline cervical specimens from women...
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Article
Sindbis virus replicon particles encoding calreticulin linked to a tumor antigen generate long-term tumor-specific immunity
Alphavirus vectors have emerged as a promising strategy for the development of cancer vaccines and gene therapy applications. In this study, we used the replication-defective vaccine vector SIN replicon partic...
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Article
Hypoxia-induced apoptosis in endothelial cells and embryonic stem cells
Background: To evaluate the influence of hypoxia and molecular events in endothelial and embryonic stem cells.
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Article
CD8+ T cells, NK cells and IFN-γ are important for control of tumor with downregulated MHC class I expression by DNA vaccination
One of the major hurdles facing cancer immunotherapy is that cancers may downregulate expression of MHC class I molecules. The development of a suitable tumor model with downregulated MHC class I expression is...
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Article
Enhancement of suicidal DNA vaccine potency by linking Mycobacterium tuberculosis heat shock protein 70 to an antigen
Naked DNA vaccines represent an attractive approach for generating antigen-specific immunity because of their stability and simplicity of delivery. There are particular concerns with DNA vaccines however, such...
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Article
Recombinant DNA vaccines protect against tumors that are resistant to recombinant vaccinia vaccines containing the same gene
Antigen-specific cancer immunotherapy involves the delivery of tumor-associated antigen to the host for the generation of tumor-specific immune responses and antitumor effects. We hypothesized that different d...