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  1. Article

    Coinjection of IL2 DNA enhances E7-specific antitumor immunity elicited by intravaginal therapeutic HPV DNA vaccination with electroporation

    The generation and use of therapeutic human papillomavirus (HPV) DNA vaccines represent an appealing treatment method against HPV-associated cervical cancer owing to their safety and durability. Previously, we...

    Y Sun, S Peng, A Yang, E Farmer, T-C Wu, C-F Hung in Gene Therapy (2017)

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  2. Article

    Open Access

    Intravaginal HPV DNA vaccination with electroporation induces local CD8+ T-cell immune responses and antitumor effects against cervicovaginal tumors

    Therapeutic human papillomavirus (HPV) vaccines have the potential to inhibit the progression of an established HPV infection to precancer and cancer lesions by targeting HPV oncoproteins. We have previously d...

    Y Sun, S Peng, J Qiu, J Miao, B Yang, J Jeang, C-F Hung, T-C Wu in Gene Therapy (2015)

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  3. No Access

    Article

    Innovative DNA vaccine for human papillomavirus (HPV)-associated head and neck cancer

    Human papillomavirus (HPV), particularly type 16, has been associated with a subset of head and neck cancers. The viral-encoded oncogenic proteins E6 and E7 represent ideal targets for immunotherapy against HP...

    A Wu, Q Zeng, T H Kang, S Peng, E Roosinovich, S I Pai, C-F Hung in Gene Therapy (2011)

  4. No Access

    Article

    Efficient delivery of DNA vaccines using human papillomavirus pseudovirions

    We have examined non-replicative human papillomavirus (HPV) pseudovirions as an approach in the delivery of naked DNA vaccines without safety concerns associated with live viral vectors. In this study, we have...

    S Peng, A Monie, T H Kang, C-F Hung, R Roden, T-C Wu in Gene Therapy (2010)

  5. No Access

    Article

    Enhancing DNA vaccine potency by co-administration of xenogenic MHC class-I DNA

    Intramuscular administration of DNA vaccines can lead to the generation of antigen-specific immune responses through cross-priming mechanisms. We propose a strategy that is capable of leading to local inflamma...

    T H Kang, J-Y Chung, A Monie, S I Pai, C-F Hung, T-C Wu in Gene Therapy (2010)

  6. No Access

    Article

    Multitarget therapy of malignant cancers by the head-to-tail tandem array multiple shRNAs expression system

    Coexpression of multiple shRNAs can simultaneously inhibit multiple genes or target multiple sites on a single gene. These approaches can be used for dissecting complex signaling pathways and even be applied t...

    T L Cheng, C F Teng, W H Tsai, C W Yeh, M P Wu, H C Hsu, C F Hung… in Cancer Gene Therapy (2009)

  7. No Access

    Article

    Enhancement of CD4+ T-cell help reverses the doxorubicin-induced suppression of antigen-specific immune responses in vaccinated mice

    Multimodality treatments that combine conventional cancer therapies with antigen-specific immunotherapy have emerged as promising approaches for the control of cancer. In the current study, we have explored th...

    D Kim, A Monie, Y-C Tsai, L He, M-C Wang, C-F Hung, T-C Wu in Gene Therapy (2008)

  8. No Access

    Article

    Cluster intradermal DNA vaccination rapidly induces E7-specific CD8+ T-cell immune responses leading to therapeutic antitumor effects

    Intradermal administration of DNA vaccines via a gene gun represents a feasible strategy to deliver DNA directly into the professional antigen-presenting cells (APCs) in the skin. This helps to facilitate the ...

    S Peng, C Trimble, R D Alvarez, W K Huh, Z Lin, A Monie, C-F Hung, T-C Wu in Gene Therapy (2008)

  9. Article

    Erratum: Role of IL-2 secreted by PADRE-specific CD4+ T cells in enhancing E7-specific CD8+ T-cell immune responses

    Correction to: Gene Therapy (2008) 15, 677–687; doi:10.1038/sj.gt.3303102 The authors have noticed an error in one of the affiliations. This does not include the ‘Department of Anatomy.’ Please see the correct...

    D Kim, A Monie, L He, Y-C Tsai, C-F Hung, T-C Wu in Gene Therapy (2008)

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  10. No Access

    Article

    Role of IL-2 secreted by PADRE-specific CD4+ T cells in enhancing E7-specific CD8+ T-cell immune responses

    CD4+ T helper cells are known to play an integral role in the generation of CD8+ T-cell immune responses. We have previously shown that co-administration of DNA vaccines containing E6 or E7 protein of human papil...

    D Kim, A Monie, L He, Y-C Tsai, C-F Hung, T-C Wu in Gene Therapy (2008)

  11. No Access

    Article

    Control of human mesothelin-expressing tumors by DNA vaccines

    Mesothelin has been implicated as a potential ideal target antigen for the development of antigen-specific cancer immunotherapy for the control of mesothelin-expressing cancers such as ovarian cancer, mesothel...

    C-L Chang, T-C Wu, C-F Hung in Gene Therapy (2007)

  12. No Access

    Article

    Control of mesothelin-expressing ovarian cancer using adoptive transfer of mesothelin peptide-specific CD8+ T cells

    Cancer immunotherapy targeting mesothelin represents a potentially plausible approach for the control of ovarian cancer as most ovarian cancers express high levels of mesothelin. In the current study, we creat...

    C-F Hung, Y-C Tsai, L He, T-C Wu in Gene Therapy (2007)

  13. No Access

    Article

    Vaccinia virus preferentially infects and controls human and murine ovarian tumors in mice

    Vaccinia virus has been shown to efficiently infect tumor cells. Therefore, vaccinia virus represents a potentially safe and effective antitumor agent against ovarian cancer. Here, we assessed the ability of v...

    C-F Hung, Y-C Tsai, L He, G Coukos, I Fodor, L Qin, H Levitsky, T-C Wu in Gene Therapy (2007)

  14. No Access

    Article

    Sindbis virus replicon particles encoding calreticulin linked to a tumor antigen generate long-term tumor-specific immunity

    Alphavirus vectors have emerged as a promising strategy for the development of cancer vaccines and gene therapy applications. In this study, we used the replication-defective vaccine vector SIN replicon partic...

    W-F Cheng, C-N Lee, Y-N Su, C-Y Chai, M-C Chang, J M Polo, C-F Hung… in Cancer Gene Therapy (2006)

  15. No Access

    Article

    Prospects of RNA interference therapy for cancer

    RNA interference (RNAi) is a powerful gene-silencing process that holds great promise in the field of cancer therapy. The discovery of RNAi has generated enthusiasm within the scientific community, not only be...

    S I Pai, Y-Y Lin, B Macaes, A Meneshian, C-F Hung, T-C Wu in Gene Therapy (2006)

  16. No Access

    Article

    A combination of DNA vaccines targeting human papillomavirus type 16 E6 and E7 generates potent antitumor effects

    Human papillomavirus (HPV) infects large numbers of women worldwide and is present in more than 99% of all cervical cancers. HPV E6 and E7 are two viral oncoproteins that are consistently expressed in HPV infe...

    S Peng, T T Tomson, C Trimble, L He, C-F Hung, T-C Wu in Gene Therapy (2006)

  17. No Access

    Article

    Characterization of HLA-A2-restricted HPV-16 E7-specific CD8+ T-cell immune responses induced by DNA vaccines in HLA-A2 transgenic mice

    We have recently demonstrated that linkage of DNA-encoding calreticulin to DNA-encoding human papillomavirus-16 E7 antigen strongly enhances the efficacy of DNA vaccines against E7-expressing tumors in animal ...

    S Peng, C Trimble, L He, Y-C Tsai, C-T Lin, D A K Boyd, D Pardoll, C-F Hung… in Gene Therapy (2006)

  18. No Access

    Article

    Cancer immunotherapy using a DNA vaccine encoding a single-chain trimer of MHC class I linked to an HPV-16 E6 immunodominant CTL epitope

    The potency of DNA vaccines may be affected by the efficiency of intracellular processing and MHC class I presentation of encoded antigens. Since a single-chain trimer (SCT) composed of peptide, β2-microglobul...

    C-H Huang, S Peng, L He, Y-C Tsai, D A K Boyd, T H Hansen, T-C Wu, C-F Hung in Gene Therapy (2005)

  19. No Access

    Article

    Comparison of HPV DNA vaccines employing intracellular targeting strategies

    Intradermal vaccination via gene gun efficiently delivers DNA vaccines into dendritic cells (DCs) of the skin, resulting in the activation and priming of antigen-specific T cells in vivo. In the context of DNA va...

    J W Kim, C-F Hung, J Juang, L He, T Woo Kim, D K Armstrong, S I Pai… in Gene Therapy (2004)

  20. No Access

    Article

    Enhancement of suicidal DNA vaccine potency by delaying suicidal DNA-induced cell death

    DNA-based alphaviral RNA replicon vectors, also called suicidal DNA vectors, alleviate the concerns of integration or transformation related to conventional DNA vectors since suicidal DNA vectors eventually ca...

    TW Kim, C-F Hung, J Juang, L He, JM Hardwick, T-C Wu in Gene Therapy (2004)

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