13 Result(s)
within
Toshihiro Kushibiki
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Article
Open AccessEngraftment of Transplanted Buccal Epithelial Cells onto the Urethrotomy Site, Proven Immunohistochemically in Rabbit Model; a Feat to Prevent Urethral Stricture Recurrence
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Chapter
Negative-Pressure Wound Therapy: What We Know and What We Need to Know
Negative-pressure wound therapy (NPWT) promotes wound healing by applying negative pressure to the wound surface. A quarter of a century after its introduction, NPWT has been used in various clinical condition...
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Article
Open AccessPhotocrosslinked gelatin hydrogel improves wound healing and skin flap survival by the sustained release of basic fibroblast growth factor
Biomaterials traditionally used for wound healing can act as a temporary barrier to halt bleeding, prevent infection, and enhance regeneration. Hydrogels are among the best candidates for wound healing owing t...
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Chapter
Current Topics of Optogenetics for Medical Applications Toward Therapy
The optogenetics approach uses a combination of genetic and optical methods to initiate and control functions in specific cells of biological tissues. Since the high-speed control of neuronal activity by irrad...
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Article
Measurement of blood-oxygen saturation using a photoacoustic technique in the rabbit hypoxemia model
The golden standard method to obtain accurate blood oxygen saturation is blood gas analysis that needs invasive procedure of blood sampling. Photoacoustic technique enables us to measure real-time blood oxygen...
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Article
Therapeutic activity of retroviral replicating vector-mediated prodrug activator gene therapy for pancreatic cancer
Toca 511, a retroviral replicating vector (RRV) encoding the yeast cytosine deaminase (yCD) prodrug activator gene, which mediates conversion of the prodrug 5-fluorocytosine (5-FC) to the anticancer drug 5-flu...
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Article
Numerical and experimental investigations of dependence of photoacoustic signals from gold nanoparticles on the optical properties
Gold nanoparticles (AuNPs) are used as a contrast agent of the photoacoustic (PA) imaging. The efficiency of AuNPs has been discussed with the absorption cross section. However, the effects of the scattering o...
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Article
Open AccessEffects of the approximations of light propagation on quantitative photoacoustic tomography using two-dimensional photon diffusion equation and linearization
Quantitative photoacoustic tomography (QPAT) employing a light propagation model will play an important role in medical diagnoses by quantifying the concentration of hemoglobin or a contrast agent. However, QP...
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Article
Open AccessPhotodynamic activation as a molecular switch to promote osteoblast cell differentiation via AP-1 activation
In photodynamic therapy (PDT), cells are impregnated with a photosensitizing agent that is activated by light irradiation, thereby photochemically generating reactive oxygen species (ROS). The amounts of ROS p...
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Article
Numerical evaluation of linearized image reconstruction based on finite element method for biomedical photoacoustic imaging
An image reconstruction algorithm for biomedical photoacoustic imaging is discussed. The algorithm solves the inverse problem of the photoacoustic phenomenon in biological media and images the distribution of ...
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Article
Enhanced angiogenesis by gelatin hydrogels incorporating basic fibroblast growth factor in rabbit model of hind limb ischemia
Recently we have developed new sustained release system of basic fibroblast growth factor (bFGF) using gelatin hydrogel as a carrier. Using this system, we examined the effect of topical sustained release of b...
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Chapter and Conference Paper
Adipose differentiation kinetic analysis of preadipose cells using FT-IR
Stem cells and its differentiation get a lot of attentions in the area of regenerative medicine recently. The differentiation of stem cells is mainly evaluated by the morphological analysis. Objectives in this...
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Article
Suppression of the Progress of Disseminated Pancreatic Cancer Cells by NK4 Plasmid DNA Released from Cationized Gelatin Microspheres
Purpose. NK4, composed of the NH2-terminal hairpin and subsequent four-kringle domains of hepatocyte growth factor (HGF), acts as a potent angiogenesis inhibitor. This study is an investigation to evaluate the f...
