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Chapter
Negative-Pressure Wound Therapy: What We Know and What We Need to Know
Negative-pressure wound therapy (NPWT) promotes wound healing by applying negative pressure to the wound surface. A quarter of a century after its introduction, NPWT has been used in various clinical condition...
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Article
Open AccessPolydactyly-derived allogeneic chondrocyte cell-sheet transplantation with high tibial osteotomy as regenerative therapy for knee osteoarthritis
Allogeneic cell therapies are not fully effective in treating osteoarthritis of the knee (OAK). We recently reported that transplantation of autologous chondrocyte cell-sheets along with open-wedge high tibial...
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Article
Open AccessPhotocrosslinked gelatin hydrogel improves wound healing and skin flap survival by the sustained release of basic fibroblast growth factor
Biomaterials traditionally used for wound healing can act as a temporary barrier to halt bleeding, prevent infection, and enhance regeneration. Hydrogels are among the best candidates for wound healing owing t...
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Article
Measurement of blood-oxygen saturation using a photoacoustic technique in the rabbit hypoxemia model
The golden standard method to obtain accurate blood oxygen saturation is blood gas analysis that needs invasive procedure of blood sampling. Photoacoustic technique enables us to measure real-time blood oxygen...
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Article
Open AccessCombined surgery and chondrocyte cell-sheet transplantation improves clinical and structural outcomes in knee osteoarthritis
Current cartilage regenerative therapies are not fully effective in treating osteoarthritis of the knee (OAK). We have developed chondrocyte sheets for autologous transplantation and tested these in in vitro a...
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Article
Numerical and experimental investigations of dependence of photoacoustic signals from gold nanoparticles on the optical properties
Gold nanoparticles (AuNPs) are used as a contrast agent of the photoacoustic (PA) imaging. The efficiency of AuNPs has been discussed with the absorption cross section. However, the effects of the scattering o...
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Article
Open AccessEffects of the approximations of light propagation on quantitative photoacoustic tomography using two-dimensional photon diffusion equation and linearization
Quantitative photoacoustic tomography (QPAT) employing a light propagation model will play an important role in medical diagnoses by quantifying the concentration of hemoglobin or a contrast agent. However, QP...
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Article
Open AccessUsefulness of using laser-induced photoacoustic measurement and 3.0 Tesla MRI to assess knee cartilage damage: a comparison study
T2 map** is an MRI method particularly reflective of the collagen arrangement in the cartilage, and diffusion tensor (DT) imaging captures the diffusion of water molecules. Laser-induced photoacoustic measur...
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Article
Numerical evaluation of linearized image reconstruction based on finite element method for biomedical photoacoustic imaging
An image reconstruction algorithm for biomedical photoacoustic imaging is discussed. The algorithm solves the inverse problem of the photoacoustic phenomenon in biological media and images the distribution of ...
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Article
Open AccessHuman telomerase reverse transcriptase and glucose-regulated protein 78 increase the life span of articular chondrocytes and their repair potential
Like all mammalian cells, normal adult chondrocytes have a limited replicative life span, which decreases with age. To facilitate the therapeutic use of chondrocytes from older donors, a method is needed to pr...
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Article
Open AccessThe properties of bioengineered chondrocyte sheets for cartilage regeneration
Although the clinical results of autologous chondrocyte implantation for articular cartilage defects have recently improved as a result of advanced techniques based on tissue engineering procedures, problems w...
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Article
Recent technological advancements related to articular cartilage regeneration
Some treatments for full thickness defects of the articular cartilage, such as the transplantation of cultured chondrocytes have already been performed. However, in order to overcome osteoarthritis, we must fu...
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Chapter and Conference Paper
Multifunctional evaluation of tissue engineered cartilage using nano-pulsed light for validation of regenerative medicine
There is a demand in the field of regenerative medicine for measurement technology that enables functions of engineered tissue to be determined. Articular cartilage, which has already been applied in clinical ...
