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    Therapeutic activity of retroviral replicating vector-mediated prodrug activator gene therapy for pancreatic cancer

    Toca 511, a retroviral replicating vector (RRV) encoding the yeast cytosine deaminase (yCD) prodrug activator gene, which mediates conversion of the prodrug 5-fluorocytosine (5-FC) to the anticancer drug 5-flu...

    Kazuho Inoko, Kei Hiraoka, Akihito Inagaki, Mizuna Takahashi… in Cancer Gene Therapy (2018)