8 Result(s)

Article

A retrospective study of MYC rearranged diffuse large B-cell lymphoma in the context of the new WHO and ICC classifications

Dima El-Sharkawi, Amit Sud, Catherine Prodger, Jahanzaib Khwaja… in Blood Cancer Journal (2023)

Article

Autologous stem cell transplantation for post-transplant lymphoproliferative disorders after solid organ transplantation: a retrospective analysis from the Lymphoma Working Party of the EBMT

Published data describing the efficacy and safety of autologous stem-cell transplantation (autoSCT) in post-transplant lymphoproliferative disorders (PTLD) is limited to case reports. This is a retrospective a...

Toby A. Eyre, Sophie Caillard, Herve Finel, Ariane Boumendil… in Bone Marrow Transplantation (2021)

Article

A Phase 2a cohort expansion study to assess the safety, tolerability, and preliminary efficacy of CXD101 in patients with advanced solid-organ cancer expressing HR23B or lymphoma

This Phase 2a dose expansion study was performed to assess the safety, tolerability and preliminary efficacy of the maximum tolerated dose of the oral histone de-acetylase (HDAC) inhibitor CXD101 in patients w...

Stephen W. Booth, Toby A. Eyre, John Whittaker, Leticia Campo, Lai Mun Wang… in BMC Cancer (2021)

Article

Development of a Conceptual Model of Chronic Lymphocytic Leukemia to Better Understand the Patient Experience

Understanding the patient experience is important for identifying the unmet need in chronic lymphocytic leukemia. The current study aimed to develop a comprehensive chronic lymphocytic leukemia conceptual model.

Daniel Eek, Matthew Blowfield, Calvin Krogh… in The Patient - Patient-Centered Outcomes Re… (2021)

Article

Front-Line Treatment of High Grade B Cell Non-Hodgkin Lymphoma

Rituximab-based chemoimmunotherapy has resulted in a marked improvement in the survival of diffuse large B cell lymphoma (DLBCL). We reflect upon the history front-line (1L) therapy and highlight advances in m...

Murali Kesavan, Toby A. Eyre, Graham P. Collins in Current Hematologic Malignancy Reports (2019)

Article

The STELLAR trial protocol: a prospective multicentre trial for Richter’s syndrome consisting of a randomised trial investigation CHOP-R with or without acalabrutinib for newly diagnosed RS and a single-arm platform study for evaluation of novel agents in relapsed disease

Transformation of chronic lymphocytic leukaemia (CLL) to diffuse large B-cell lymphoma (DLCBL) type Richter’s syndrome (RS) carries a dismal prognosis. Standard-of-care chemoimmunotherapy for de novo RS is ina...

Niamh Appleby, Toby A. Eyre, Maite Cabes, Aimee Jackson, Rebecca Boucher… in BMC Cancer (2019)

Article

Single arm NCRI phase II study of CHOP in combination with Ofatumumab in induction and maintenance for patients with newly diagnosed Richter’s syndrome

Transformation of B-cell chronic lymphocytic leukaemia (B-CLL) to diffuse large B cell lymphoma (DLBCL) (Richter’s syndrome (RS)) is a rare (2-15% of patients) but catastrophic complication of B-CLL. Dose-inte...

Toby A Eyre, Ruth Clifford, Corran Roberts, Lucy Boyle, Anne Francis… in BMC Cancer (2015)