9 Result(s)

Article

A phase II open label, randomised study of ipilimumab with temozolomide versus temozolomide alone after surgery and chemoradiotherapy in patients with recently diagnosed glioblastoma: the Ipi-Glio trial protocol

Median survival for patients with glioblastoma is less than a year. Standard treatment consists of surgical debulking if feasible followed by temozolomide chemo-radiotherapy. The immune checkpoint inhibitor ip...

Nicholas F. Brown, Stasya M. Ng, Claire Brooks, Tim Coutts, Jane Holmes… in BMC Cancer (2020)

Article

Results of a phase II clinical trial of 6-mercaptopurine (6MP) and methotrexate in patients with BRCA-defective tumours

Tumour cells with BRCA1/2 gene mutations demonstrate increased sensitivity to platinum and poly (ADP-ribose) polymerase (PARP) inhibitors. 6-mercaptopurine (6MP) was found to selectively kill BRCA-defective cells...

Corran Roberts, Victoria Y. Strauss, Sylwia Kopijasz… in British Journal of Cancer (2020)

Article

Erratum to: Methods for evaluating medical tests and biomarkers

Gowri Gopalakrishna, Miranda Langendam, Rob Scholten… in Diagnostic and Prognostic Research (2017)

Article

Methods for Evaluating Medical Tests and Biomarkers

Gowri Gopalakrishna, Miranda Langendam, Rob Scholten… in Diagnostic and Prognostic Research (2017)

Article

Impact of a web-based tool (WebCONSORT) to improve the reporting of randomised trials: results of a randomised controlled trial

The CONSORT Statement is an evidence-informed guideline for reporting randomised controlled trials. A number of extensions have been developed that specify additional information to report for more complex tri...

Sally Hopewell, Isabelle Boutron, Douglas G. Altman, Ginny Barbour… in BMC Medicine (2016)

Article

RADVAN: a randomised phase 2 trial of WBRT plus vandetanib for melanoma brain metastases – results and lessons learnt

Brain metastases occur in up to 75% of patients with advanced melanoma. Most are treated with whole-brain radiotherapy (WBRT), with limited effectiveness. Vandetanib, an inhibitor of vascular endothelial growt...

Avinash Gupta, Corran Roberts, Finn Tysoe, Matthew Goff… in British Journal of Cancer (2016)

Article

Epidermal Growth Factor (EGFR) copy number aberrations in esophageal and gastro-esophageal junctional carcinoma

Clinical trials of agents targeting epidermal growth factor receptor (EGFR) in esophageal carcinoma (EC) have indicated a minority subgroup responsive to anti-EGFR therapies. Other investigations suggest incre...

Åsa Dahle-Smith, David Stevenson, Doreen Massie, Graeme I. Murray… in Molecular Cytogenetics (2015)

Article

Single arm NCRI phase II study of CHOP in combination with Ofatumumab in induction and maintenance for patients with newly diagnosed Richter’s syndrome

Transformation of B-cell chronic lymphocytic leukaemia (B-CLL) to diffuse large B cell lymphoma (DLBCL) (Richter’s syndrome (RS)) is a rare (2-15% of patients) but catastrophic complication of B-CLL. Dose-inte...

Toby A Eyre, Ruth Clifford, Corran Roberts, Lucy Boyle, Anne Francis… in BMC Cancer (2015)

Article

A phase II clinical trial of 6-mercaptopurine (6MP) and methotrexate in patients with BRCA defective tumours: a study protocol

BRCA1 and BRCA2 genes are critical in homologous recombination DNA repair and have been implicated in familial breast and ovarian cancer tumorigenesis. Tumour cells with these mutations demonstrate increased s...

Shibani Nicum, Corran Roberts, Lucy Boyle, Sylwia Kopijasz, Charlie Gourley… in BMC Cancer (2014)