8 Result(s)

Article

PRMT5 inhibition shows in vitro efficacy against H3K27M-altered diffuse midline glioma, but does not extend survival in vivo

H3K27-altered Diffuse Midline Glioma (DMG) is a universally fatal paediatric brainstem tumour. The prevalent driver mutation H3K27M creates a unique epigenetic landscape that may also establish therapeutic vul...

Elizabeth J. Brown, Leire Balaguer-Lluna, Adam P. Cribbs… in Scientific Reports (2024)

Article

WNT5A-ROR2 axis mediates VEGF dependence of BRAF mutant melanoma

Despite recent advances, approximately 50% of patient with metastatic melanoma eventually succumb to the disease. Patients with melanomas harboring a BRAF mutation (BRAF^Mut) have a worse prognosis than those with...

Nicholas Coupe, Lina Guo, Esther Bridges, Leticia Campo… in Cellular Oncology (2023)

Article

Author Correction: Tuning microtubule dynamics to enhance cancer therapy by modulating FER-mediated CRMP2 phosphorylation

Yiyan Zheng, Ritika Sethi, Lingegowda S. Mangala, Charlotte Taylor… in Nature Communications (2022)

Article

A Phase 2a cohort expansion study to assess the safety, tolerability, and preliminary efficacy of CXD101 in patients with advanced solid-organ cancer expressing HR23B or lymphoma

This Phase 2a dose expansion study was performed to assess the safety, tolerability and preliminary efficacy of the maximum tolerated dose of the oral histone de-acetylase (HDAC) inhibitor CXD101 in patients w...

Stephen W. Booth, Toby A. Eyre, John Whittaker, Leticia Campo, Lai Mun Wang… in BMC Cancer (2021)

Article

Quantifying cell death induced by doxorubicin, hyperthermia or HIFU ablation with flow cytometry

Triggered release and targeted drug delivery of potent anti-cancer agents using hyperthermia-mediated focused-ultrasound (FUS) is gaining momentum in the clinical setting. In early phase studies, tissue biopsy...

Paul Christopher Lyon, Visa Suomi, Philip Jakeman, Leticia Campo… in Scientific Reports (2021)

Article

Tuning microtubule dynamics to enhance cancer therapy by modulating FER-mediated CRMP2 phosphorylation

Though used widely in cancer therapy, paclitaxel only elicits a response in a fraction of patients. A strong determinant of paclitaxel tumor response is the state of microtubule dynamic instability. However, w...

Yiyan Zheng, Ritika Sethi, Lingegowda S. Mangala, Charlotte Taylor… in Nature Communications (2018)

Article

The prolyl hydroxylase enzymes are positively associated with hypoxia-inducible factor-1α and vascular endothelial growth factor in human breast cancer and alter in response to primary systemic treatment with epirubicin and tamoxifen

The purpose of the present study was to investigate the relationship of expression of hypoxia inducible factor (HIF)-1α-modifying enzymes prolyl hydroxylase (PHD)1, PHD2 and PHD3 to response of tumours and sur...

Stephen B Fox, Daniele Generali, Alfredo Berruti, Maria P Brizzi… in Breast Cancer Research (2011)

Article

Cytoplasmic location of factor-inhibiting hypoxia-inducible factor is associated with an enhanced hypoxic response and a shorter survival in invasive breast cancer

Hypoxia-inducible factor (HIF)-1α levels in invasive breast carcinoma have been shown to be an adverse prognostic indicator. Cellular HIF-1α activity is regulated by factor-inhibiting hypoxia-inducible factor ...

Ern Yu Tan, Leticia Campo, Cheng Han, Helen Turley… in Breast Cancer Research (2007)