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Open AccessGenome-wide association analysis and Mendelian randomization proteomics identify drug targets for heart failure
We conduct a large-scale meta-analysis of heart failure genome-wide association studies (GWAS) consisting of over 90,000 heart failure cases and more than 1 million control individuals of European ancestry to ...
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Open AccessA Phase 2a cohort expansion study to assess the safety, tolerability, and preliminary efficacy of CXD101 in patients with advanced solid-organ cancer expressing HR23B or lymphoma
This Phase 2a dose expansion study was performed to assess the safety, tolerability and preliminary efficacy of the maximum tolerated dose of the oral histone de-acetylase (HDAC) inhibitor CXD101 in patients w...
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Open AccessExome sequencing and characterization of 49,960 individuals in the UK Biobank
The UK Biobank is a prospective study of 502,543 individuals, combining extensive phenotypic and genotypic data with streamlined access for researchers around the world1. Here we describe the release of exome-seq...
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Open AccessFormalising recall by genotype as an efficient approach to detailed phenoty** and causal inference
Detailed phenoty** is required to deepen our understanding of the biological mechanisms behind genetic associations. In addition, the impact of potentially modifiable risk factors on disease requires analyti...
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Article
Open AccessMendelian Randomisation study of the influence of eGFR on coronary heart disease
Impaired kidney function, as measured by reduced estimated glomerular filtration rate (eGFR), has been associated with increased risk of coronary heart disease (CHD) in observational studies, but it is unclear...
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Article
Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease
Integration of genome-wide expression profiling with linkage analysis is a new approach to identifying genes underlying complex traits. We applied this approach to the regulation of gene expression in the BXH/...
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Map** multiple QTL of different effects: comparison of a simple sequential testing strategy and multiple QTL map**
The aim of this study was to explore, by computer simulation, the map** of QTLs in a realistic but complex situation of many (linked) QTLs with different effects, and to compare two QTL map** methods. A no...
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Reflections on the Changing Nature of Projects
As we have moved from building great physical monuments such as the pyramids to ethereal constructions like computer operating systems, the nature of project management changes. In pyramid construction progres...
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Implementing a Bidding Model
A major British construction company spent 4 years develo**, experimenting, evolving and implementing a probabilistic bidding model. This paper chronicles the progress and describes the results achieved. Ove...
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The Economic Effects of Floods
