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  1. Article

    Open Access

    A Phase 2a cohort expansion study to assess the safety, tolerability, and preliminary efficacy of CXD101 in patients with advanced solid-organ cancer expressing HR23B or lymphoma

    This Phase 2a dose expansion study was performed to assess the safety, tolerability and preliminary efficacy of the maximum tolerated dose of the oral histone de-acetylase (HDAC) inhibitor CXD101 in patients w...

    Stephen W. Booth, Toby A. Eyre, John Whittaker, Leticia Campo, Lai Mun Wang… in BMC Cancer (2021)

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  2. Article

    Open Access

    Epac activation, altered calcium homeostasis and ventricular arrhythmogenesis in the murine heart

    The recently described exchange protein directly activated by cAMP (Epac) has been implicated in distinct protein kinase A-independent cellular signalling pathways. We investigated the role of Epac activation in ...

    Sandeep S. Hothi, Iman S. Gurung… in Pflügers Archiv - European Journal of Phys… (2008)

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