17 Result(s)

Article

Angiogenesis-associated pathways play critical roles in neonatal sepsis outcomes

Neonatal sepsis is a major cause of childhood mortality. Limited diagnostic tools and mechanistic insights have hampered our abilities to develop prophylactic or therapeutic interventions. Biomarkers in human ...

Mario Fidanza, Julie Hibbert, Erica Acton, Danny Harbeson… in Scientific Reports (2024)

Article

Implications of Non-Specific Effects for Testing, Approving, and Regulating Vaccines

The current framework for testing and regulating vaccines was established before the realization that vaccines, in addition to their effect against the vaccine-specific disease, may also have “non-specific eff...

Christine Stabell Benn, Nelly Amenyogbe, Anders Björkman… in Drug Safety (2023)

Article

Revaccination with Bacille Calmette-Guérin (BCG) is associated with an increased risk of abscess and lymphadenopathy

The reported frequency and types of adverse events following initial vaccination and revaccination with Bacille Calmette-Guérin (BCG) varies worldwide. Using active surveillance in a randomised controlled tria...

Paola Villanueva, Ushma Wadia, Nigel Crawford, Nicole L. Messina… in npj Vaccines (2022)

Article

A cluster randomized trial of interferon ß-1a for the reduction of transmission of SARS-Cov-2: protocol for the Containing Coronavirus Disease 19 trial (ConCorD-19)

SARS-CoV-2 infection rapidly spreads in populations due to the high rates of community transmission. Interrupting the shedding of SARS-CoV-2 may reduce the incidence of Coronavirus Disease 19 (COVID-19). Herei...

Carolina Iturriaga, Nat Eiffler, Rad Aniba, Rym Ben-Othman… in BMC Infectious Diseases (2021)

Article

Immunological mechanisms of vaccine-induced protection against COVID-19 in humans

Most COVID-19 vaccines are designed to elicit immune responses, ideally neutralizing antibodies (NAbs), against the SARS-CoV-2 spike protein. Several vaccines, including mRNA, adenoviral-vectored, protein subu...

Manish Sadarangani, Arnaud Marchant, Tobias R. Kollmann in Nature Reviews Immunology (2021)

Article

The non-specific and sex-differential effects of vaccines

The textbook view of vaccination is that it functions to induce immune memory of the specific pathogen components of the vaccine, leading to a quantitatively and qualitatively better response if the host is ex...

Peter Aaby, Christine Stabell Benn, Katie L. Flanagan… in Nature Reviews Immunology (2020)

Article

Dynamic molecular changes during the first week of human life follow a robust developmental trajectory

Systems biology can unravel complex biology but has not been extensively applied to human newborns, a group highly vulnerable to a wide range of diseases. We optimized methods to extract transcriptomic, proteo...

Amy H. Lee, Casey P. Shannon, Nelly Amenyogbe, Tue B. Bennike… in Nature Communications (2019)

Article

Immunity and immunopathology in early human life

Tobias R. Kollmann, Arnaud Marchant in Seminars in Immunopathology (2017)

Article

Lack of broad functional differences in immunity in fully vaccinated vs. unvaccinated children

Concerns have been raised that with an increase in the number of vaccines administered early in life, immune development could be altered, leading to either increased or decreased immune reactivity.

Ashley M. Sherrid, Candice E. Ruck, Darren Sutherland, Bing Cai… in Pediatric Research (2017)

Article

Attenuated innate immune defenses in very premature neonates during the neonatal period

Antimicrobial responses have been shown to be profoundly attenuated in very preterm neonates when examined on cord blood. However, we lack data on these responses at the time these neonates are most vulnerable...

Elizabeth A. Marchant, Bernard Kan, Ashish A. Sharma… in Pediatric Research (2015)

Article

Nonspecific effects of neonatal and infant vaccination: public-health, immunological and conceptual challenges

Neonates represent a challenging group for vaccination. Effective vaccine programs will need to take into account a number of factors including gender and non-specific vaccine effects.

Peter Aaby, Tobias R Kollmann, Christine Stabell Benn in Nature Immunology (2014)

Article

Harnessing microbiome and probiotic research in sub-Saharan Africa: recommendations from an African workshop

To augment capacity-building for microbiome and probiotic research in Africa, a workshop was held in Nairobi, Kenya, at which researchers discussed human, animal, insect, and agricultural microbiome and probio...

Gregor Reid, Nicholas Nduti, Wilbert Sybesma, Remco Kort, Tobias R Kollmann… in Microbiome (2014)

Article

Flow cytometry data standards

Flow cytometry is a widely used analytical technique for examining microscopic particles, such as cells. The Flow Cytometry Standard (FCS) was developed in 1984 for storing flow data and it is supported by all...

Josef Spidlen, Parisa Shooshtari, Tobias R Kollmann, Ryan R Brinkman in BMC Research Notes (2011)

Article

Functional characterization of human variants of NFKBIA: a key regulator of immune responsiveness implicated in susceptibility to infectious and inflammatory disease

Salman Ali, Aaron Hirschfeld, Rachel Victor… in Allergy, Asthma & Clinical Immunology (2010)

Article

A bacterial immune-prophylactic approach against asthma for infants and children

Daniela IM Loeffler, Charis Segeritz, Bing Cai… in Allergy, Asthma & Clinical Immunology (2010)