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Article
Antibiotic use in children hospitalised for influenza, 2010–2021: the Canadian Immunization Monitoring Program Active (IMPACT)
To determine characteristics associated with inappropriate antibiotic use amongst children hospitalised for influenza.
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Article
Open AccessAdaptive immune responses to two-dose COVID-19 vaccine series in healthy Canadian adults ≥ 50 years: a prospective, observational cohort study
To evaluate immune responses to COVID-19 vaccines in adults aged 50 years and older, spike protein (S)-specific antibody concentration, avidity, and function (via angiotensin-converting enzyme 2 (ACE2) inhibit...
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Article
Open AccessFactors associated with SARS-CoV-2 infection in unvaccinated children and young adults
Pediatric COVID-19 cases are often mild or asymptomatic, which has complicated estimations of disease burden using existing testing practices. We aimed to determine the age-specific population seropositivity a...
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Article
Paediatric inflammatory multisystem syndrome in Canada: population-based surveillance and role of SARS-CoV-2 linkage
Paediatric inflammatory multisystem syndrome (PIMS) is a rare condition temporally associated with SARS-CoV-2 infection. Using national surveillance data, we compare presenting features and outcomes among chil...
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Article
SARS-CoV-2 infection in technology-dependent children: a multicenter case series
The objective of this study was to describe the clinical course and outcomes in children with technology dependence (TD) hospitalized with SARS-CoV-2 infection.
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Article
Factors associated with intention to receive vaccines for bacterial sexually transmitted infections among young HPV-vaccinated Canadian women
The aim of this study was to explore the acceptability of bacterial STI vaccines among young HPV-vaccinated Canadian women to inform future vaccine program implementation.
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Article
Open AccessTransition to endemic: acceptance of additional COVID-19 vaccine doses among Canadian adults in a national cross-sectional survey
Additional doses of COVID-19 vaccine have been proposed as solutions to waning immunity and decreased effectiveness of primary doses against infection with new SARS-CoV-2 variants. However, the effectiveness o...
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Article
Authors’ response: Re: Reifferscheid et al., “COVID-19 vaccine uptake and intention during pregnancy in Canada”
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Article
Open AccessCOVID-19 vaccine uptake and intention during pregnancy in Canada
To investigate COVID-19 vaccine uptake and intent among pregnant people in Canada, and determine associated factors.
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Article
Intention to Receive a COVID-19 Vaccine by HIV Status Among a Population-Based Sample of Women and Gender Diverse Individuals in British Columbia, Canada
COVID-19 vaccination is recommended for people living with HIV (PLWH), among whom social inequities and co-morbidities may drive risks of COVID-19 infection and outcome severity. Among a provincial (British Co...
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Article
Infants hospitalized for acute COVID-19: disease severity in a multicenter cohort study
Age is the most important determinant of COVID-19 severity. Infectious disease severity by age is typically J-shaped, with infants and the elderly carrying a high burden of disease. We report on the comparativ...
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Article
Open AccessPhysician vaccination practices in mild to moderate inborn errors of immunity and retrospective review of vaccine completeness in IEI: results from the Canadian Immunization Research Network
Safety and effectiveness concerns may preclude physicians from recommending vaccination in mild/moderate inborn errors of immunity (IEI). This study describes attitudes and practices regarding vaccination amon...
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Article
Open AccessChild transmission of SARS-CoV-2: a systematic review and meta-analysis
Understanding of the role of children in COVID-19 transmission has significant implications for school and childcare policies, as well as appropriate targeting of vaccine campaigns. The objective of this syste...
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Article
Immunological mechanisms of vaccine-induced protection against COVID-19 in humans
Most COVID-19 vaccines are designed to elicit immune responses, ideally neutralizing antibodies (NAbs), against the SARS-CoV-2 spike protein. Several vaccines, including mRNA, adenoviral-vectored, protein subu...
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Article
Open AccessIntention to receive a COVID-19 vaccine: results from a population-based survey in Canada
The success of any COVID-19 vaccine program ultimately depends on high vaccine uptake. This study determined overall intention to receive a COVID-19 vaccine and identified factors that predict intentions to be...
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Chapter
Meningococcal Vaccines
Neisseria meningitidis (the meningococcus) is a Gram-negative diplococcus, which causes meningitis and septicaemia with a high case fatality rate and many survivors suffering from long-term neurological and non-n...
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Article
Open AccessStudy protocol: NeoCLEAR: Neonatal Champagne Lumbar punctures Every time – An RCT: a multicentre, randomised controlled 2 × 2 factorial trial to investigate techniques to increase lumbar puncture success
The neonatal period carries the highest risk of bacterial meningitis (~ 1 in 5000 births), bearing high mortality (~ 10%) and morbidity (20–50%) rates. Lumbar puncture (LP) remains essential to the diagnosis o...
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Article
Open AccessThe prevalence and clinical characteristics of pertussis-associated pneumonia among infants in Botswana
There are scant data on the prevalence and clinical course of pertussis disease among infants with pneumonia in low- and middle-income countries. While pertussis vaccination coverage is high (≥90%) among infan...
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Article
Open AccessComparative transcriptomics between species attributes reactogenicity pathways induced by the capsular group B meningococcal vaccine, 4CMenB, to the membrane-bound endotoxin of its outer membrane vesicle component
The capsular group B meningococcal (MenB) four component vaccine (4CMenB) has been licensed for the prevention of invasive disease caused by MenB. The vaccine causes fever in infants, particularly when given i...
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Chapter
Meningococcal Vaccines
Meningococcal disease was first described in Europe as a characteristic outbreak in Geneva in 1805. Neisseria meningitidis (the meningococcus) is a Gram-negative diplococcus, divided into capsular groups determin...
