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Article
Assessing the generation of tissue resident memory T cells by vaccines
Vaccines have been a hugely successful public health intervention, virtually eliminating many once common diseases of childhood. However, they have had less success in controlling endemic pathogens including Myco...
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Article
Author Correction: Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis
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Article
Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis
Gasdermins, a family of five pore-forming proteins (GSDMA–GSDME) in humans expressed predominantly in the skin, mucosa and immune sentinel cells, are key executioners of inflammatory cell death (pyroptosis), w...
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Open AccessEpicutaneous immunization with modified vaccinia Ankara viral vectors generates superior T cell immunity against a respiratory viral challenge
Modified Vaccinia Ankara (MVA) was recently approved as a smallpox vaccine. Variola is transmitted by respiratory droplets and MVA immunization by skin scarification (s.s.) protected mice far more effectively ...
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Publisher Correction: Molecular analysis of primary melanoma T cells identifies patients at risk for metastatic recurrence
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Molecular analysis of primary melanoma T cells identifies patients at risk for metastatic recurrence
Primary melanomas >1 mm thickness are potentially curable by resection, but can recur metastatically. We assessed the prognostic value of the T-cell fraction (TCFr) and repertoire T-cell clonality, measured by...
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Resident Memory T Cells in the Tumor Microenvironment
Tissue-resident memory T (TRM) cells are strategically positioned within the epithelial layers of many tissues to provide enduring site-specific immunological memory. This unique T-cell lineage is endowed with th...
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Article
T cells and the skin: from protective immunity to inflammatory skin disorders
Skin is our primary interface with the environment, and T cells are crucial for orchestrating host immune responses against pathogenic microorganisms at this site. Effective skin immune responses require the g...
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Article
Publisher Correction: Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS–STING signalling
In this Letter, Supplementary Fig. 1 was missing. This error has been corrected online.
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Article
Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS–STING signalling
Cytosolic DNA triggers innate immune responses through the activation of cyclic GMP–AMP synthase (cGAS) and production of the cyclic dinucleotide second messenger 2′,3′-cyclic GMP–AMP (cGAMP)1–4. 2′,3′-cGAMP is a...
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Article
Open AccessAprepitant for refractory cutaneous T-cell lymphoma-associated pruritus: 4 cases and a review of the literature
Aprepitant is an FDA-approved medication for chemotherapy-induced nausea and vomiting. It blocks substance P binding to neurokinin-1; substance P has been implicated in itch pathways both as a local and global...
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Article
Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism
FABP4 and FABP5 are important for the maintenance, longevity and function of CD8+ tissue-resident memory T cells, which use oxidative metabolism of exogenous free fatty acids to persist in tissues and to mediate ...
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Article
Open AccessSkin CD4+ memory T cells exhibit combined cluster-mediated retention and equilibration with the circulation
Although memory T cells within barrier tissues can persist as permanent residents, at least some exchange with blood. The extent to which this occurs is unclear. Here we show that memory CD4+ T cells in mouse ski...
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Article
The emerging role of resident memory T cells in protective immunity and inflammatory disease
Tissue-resident memory T cells are increasingly being linked to human tissue-specific immune and inflammatory disease. These roles are discussed in this review.
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Article
Common clonal origin of central and resident memory T cells following skin immunization
Following skin immunization a common naïve T cell precursor gives rise to resident and central memory T cells, which mediate rapid and delayed skin immune responses, respectively.
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Article
Inhibiting Janus kinases to treat alopecia areata
Alopecia areata is an immune-mediated, nonscarring form of hair loss. A new study using human clinical samples and a mouse model demonstrates that CD8αβ+NKG2D+ T effector memory cells mediate alopecia areata in p...
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Article
CXCR4 pathway associated with family history of melanoma
Genetic predisposition plays a major role in the etiology of melanoma, but known genetic markers only account for a limited fraction of family-history-associated melanoma cases. Expression microarrays have of...
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Article
Robust tumor immunity to melanoma mediated by interleukin-9–producing T cells
In this issue, Thomas Kupper and colleagues report that mice deficient for ROR-γ or interleukin-23 (IL-23) receptor showed impaired melanoma growth. Tumor growth inhibition was dependent in part on IL-9 and T ...
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Article
Skin infection generates non-migratory memory CD8+ TRM cells providing global skin immunity
Local skin infection is shown to generate long-lived T cells that reside throughout the skin and are potent effector cells, superior to circulating memory T cells in providing rapid long-term protection again ...
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Article
Interleukin-16 as a Marker of Sézary Syndrome Onset and Stage
Sézary syndrome is one of the most common forms of cutaneous T cell lymphoma (CTCL). It is characterized by skin infiltration of malignant T cells. We examined interleukin-16, a potent T cell chemoattractant a...
