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Author Correction: Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis
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Article
Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis
Gasdermins, a family of five pore-forming proteins (GSDMA–GSDME) in humans expressed predominantly in the skin, mucosa and immune sentinel cells, are key executioners of inflammatory cell death (pyroptosis), w...
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Article
Open AccessMATHLA: a robust framework for HLA-peptide binding prediction integrating bidirectional LSTM and multiple head attention mechanism
Accurate prediction of binding between class I human leukocyte antigen (HLA) and neoepitope is critical for target identification within personalized T-cell based immunotherapy. Many recent prediction tools de...
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Article
Open AccessEpicutaneous immunization with modified vaccinia Ankara viral vectors generates superior T cell immunity against a respiratory viral challenge
Modified Vaccinia Ankara (MVA) was recently approved as a smallpox vaccine. Variola is transmitted by respiratory droplets and MVA immunization by skin scarification (s.s.) protected mice far more effectively ...
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Article
Open AccessA mutation that blocks integrin α4β7 activation prevents adaptive immune-mediated colitis without increasing susceptibility to innate colitis
β7 integrins are responsible for the efficient recruitment of lymphocytes from the blood and their retention in gut-associated lymphoid tissues. Integrin α4β7 binds MAdCAM-1, mediating rolling adhesion of lymphoc...
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Article
Publisher Correction: Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS–STING signalling
In this Letter, Supplementary Fig. 1 was missing. This error has been corrected online.
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Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS–STING signalling
Cytosolic DNA triggers innate immune responses through the activation of cyclic GMP–AMP synthase (cGAS) and production of the cyclic dinucleotide second messenger 2′,3′-cyclic GMP–AMP (cGAMP)1–4. 2′,3′-cGAMP is a...
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Article
Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism
FABP4 and FABP5 are important for the maintenance, longevity and function of CD8+ tissue-resident memory T cells, which use oxidative metabolism of exogenous free fatty acids to persist in tissues and to mediate ...
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Article
Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
Caspase-mediated cleavage of gasdermin D, previously shown to mediate pyroptosis, acts by inducing oligomerization and pore formation in cell membranes.
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Open AccessPlacental gene-expression profiles of intrahepatic cholestasis of pregnancy reveal involvement of multiple molecular pathways in blood vessel formation and inflammation
Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-associated liver disease with potentially deleterious consequences for the fetus, particularly when maternal serum bile-acid concentration >40 μM. How...
