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Open AccessCombination bromo- and extraterminal domain and poly (ADP-ribose) polymerase inhibition synergistically enhances DNA damage and inhibits neuroblastoma tumorigenesis
JQ1 is a bromo- and extraterminal (BET) domain inhibitor that downregulates MYC expression and impairs the DNA damage response. Poly (ADP-ribose) polymerase (PARP) inhibitors prevent DNA damage sensing and repair...
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Preoperative spinal angiography decreases risk of spinal ischemia in pediatric posterior thoracic tumor resection
Resection of pediatric posterior thoracic tumors (PTTs) can be complicated by Artery of Adamkiewicz (AKA) injury. Post-op spinal ischemia occurs in approx. 3.2% of patients, typically due to iatrogenic vascula...
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Open AccessSkin T cells maintain their diversity and functionality in the elderly
Recent studies have highlighted that human resident memory T cells (TRM) are functionally distinct from circulating T cells. Thus, it can be postulated that skin T cells age differently from blood-circulating T c...
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Open AccessSpatially and cell-type resolved quantitative proteomic atlas of healthy human skin
Human skin provides both physical integrity and immunological protection from the external environment using functionally distinct layers, cell types and extracellular matrix. Despite its central role in human...
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Publisher Correction: Molecular analysis of primary melanoma T cells identifies patients at risk for metastatic recurrence
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Molecular analysis of primary melanoma T cells identifies patients at risk for metastatic recurrence
Primary melanomas >1 mm thickness are potentially curable by resection, but can recur metastatically. We assessed the prognostic value of the T-cell fraction (TCFr) and repertoire T-cell clonality, measured by...
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Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism
FABP4 and FABP5 are important for the maintenance, longevity and function of CD8+ tissue-resident memory T cells, which use oxidative metabolism of exogenous free fatty acids to persist in tissues and to mediate ...
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TH9 cells in skin disorders
Interleukin 9 secreting TH9 cells have been proposed as the latest addition to the family of T helper cell subsets. While a growing body of evidence from animal models points to important roles for these cells in...
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Topical treatment of melanoma metastases with imiquimod, plus administration of a cancer vaccine, promotes immune signatures in the metastases
Infiltration of cancers by T cells is associated with improved patient survival and response to immune therapies; however, optimal approaches to induce T cell infiltration of tumors are not known. This study w...
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Open AccessPilot clinical trials testing the safety and effects on the metastatic melanoma microenvironment of intratumoral interferon-gamma or imiquimod, plus a multipeptide melanoma vaccine
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Common clonal origin of central and resident memory T cells following skin immunization
Following skin immunization a common naïve T cell precursor gives rise to resident and central memory T cells, which mediate rapid and delayed skin immune responses, respectively.
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Robust tumor immunity to melanoma mediated by interleukin-9–producing T cells
In this issue, Thomas Kupper and colleagues report that mice deficient for ROR-γ or interleukin-23 (IL-23) receptor showed impaired melanoma growth. Tumor growth inhibition was dependent in part on IL-9 and T ...
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Skin infection generates non-migratory memory CD8+ TRM cells providing global skin immunity
Local skin infection is shown to generate long-lived T cells that reside throughout the skin and are potent effector cells, superior to circulating memory T cells in providing rapid long-term protection again ...
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CD1a-autoreactive T cells are a normal component of the human αβ T cell repertoire
The functions of the human T cell repertoires that recognize different CD1 molecules remain unknown. Moody and co-workers show that many CD1a-autoreactive T cells home to skin, where they produce IL-22.
