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Article
Open AccessExpression ratio of the TGFβ-inducible gene MYO10 is prognostic for overall survival of squamous cell lung cancer patients and predicts chemotherapy response
In lung cancer a deregulation of Transforming Growth Factor-β (TGFβ) signaling has been observed. Yet, the impact of TGFβ in squamous cell carcinoma of the lung (LUSC) remained to be determined. We combined ph...
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Article
Open AccessTumour cell proliferation (Ki-67) in non-small cell lung cancer: a critical reappraisal of its prognostic role
Uncontrolled proliferation is a hallmark of malignant tumour growth. Its prognostic role in non-small cell lung cancer (NSCLC) has been investigated in numerous studies with controversial results. We aimed to ...
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Article
Survival and prognostic factors in non-small cell lung cancer patients with spinal bone metastases
For palliative care of spinal bone metastases, stability assessment is of crucial importance. Pathological fractures, instability-related patient immobility and the extent of bone metastasis have been reported...
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Article
Open AccessTumour-site-dependent expression profile of angiogenic factors in tumour-associated stroma of primary colorectal cancer and metastases
Tumour-associated stroma has a critical role in tumour proliferation. Our aim was to determine a specific protein expression profile of stromal angiogenic cytokines and matrix metalloproteinases (MMPs) to iden...
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Article
Epigenetic screen identifies genotype-specific promoter DNA methylation and oncogenic potential of CHRNB4
Genome-wide association studies have highlighted three major lung cancer susceptibility regions at 15q25.1, 5p15.33 and 6p21.33. To gain insight into the possible mechanistic relevance of the genes in these re...
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Article
Antibodies to aquaporin-4 in non-small cell lung cancer: a study on 50 patients
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Article
Histone macroH2A isoforms predict the risk of lung cancer recurrence
Lung cancer is the leading cause of cancer deaths. Despite optimal diagnosis and early treatment, many patients die of recurrent disease. There are no sufficiently useful biomarkers to predict the risk of tumo...
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Article
FRMD3, a novel putative tumour suppressor in NSCLC
Lung cancer including non-small cell lung carcinoma (NSCLC) represents a leading cause of cancer death in Western countries. Yet, understanding its pathobiology to improve early diagnosis and therapeutic strat...
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Chapter
Chirurgische Therapie von Lungenmetastasen
Im Sektionsgut der an malignen Tumoren verstorbenen Patienten findet sich bei bis zu 30% eine Metastasierung in die Lunge (Willis 1967). Gilbert und Kagan (1976) fanden bei mehr als 20% der Patienten eine Meta...
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Article
Open AccessCYFRA 21-1 is a prognostic determinant in non-small-cell lung cancer: results of a meta-analysis in 2063 patients
The purpose of this study was to determine the prognostic significance of a high pretreatment serum CYFRA 21-1 level (a cytokeratin 19 fragment) adjusted for the effects of well-known co-variables in non-small...
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Chapter
Tumor-Marker — Bedeutung für Diagnostik und Verlaufskontrolle
Tumor-Marker sind Substanzen, deren Auftreten bzw. erhöhte Konzentration in Körperflüssigkeiten (humorale Tumormarker) oder verstärkte zelluläre Expression (zelluläre Tumormarker) Rückschlüsse aufdas Vorliegen...
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Chapter and Conference Paper
Wertigkeit ausgedehnter chirurgischer Resektionen in der Behandlung von Pancoast-Tumoren
Between 1986 and 1995, 46 patients suffering from pancoast-tumors underwent surgery alone or surgery in combination with pre and/or postoperative radiotherapy. Completeness of resection (R0 in 24 cases) and media...
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Chapter and Conference Paper
Lungenmetastasen: Tumorreduktion als onkologisches Konzept
The principle of surgery for lung metastases is the removal of all lesions in the lung that are either visible or detectable by palpation. This may be combined with complete dissection of all ipsilateral lymph...
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Chapter
Chirurgische Therapie der Lungenmetastasen
Im Sektionsgut der an malignen Tumoren gestorbenen Patienten findet sich zu 30% eine Metastasierung in die Lunge (Willis 1967). Gilbert u. Kagan (1976) fanden bei mehr als 20% der Patienten eine Metastasierung...
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Chapter
Tumormarker — ihre Bedeutung für Diagnostik und Verlaufskontrolle des Bronchialkarzinoms
Unter Tumormarkern versteht man Substanzen, die bei bestehendem malignen Leiden in erhöhter Konzentration in Körperflüssigkeiten vorkommen oder verstärkt zellulär exprimiert werden.
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Chapter
Chirurgische Therapie des Bronchialkarzinoms
Die Resektion des Bronchialkarzinoms ist die effektivste Therapieform, um den Primärtumor kurativ zu entfernen. Die Strahlentherapie auch in Kombination mit der Chemotherapie erreicht eine Palliation, und in w...
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Article
Inkomplette Resektionen bei Bronchialcarcinom: Morbidität und Prognose
Residual tumor (R1) was proven at the proximal bronchial resection margin in 88 (3.6 %) of 2464 cases of lung cancer following lung resection and standard lymph node dissection. Postoperative complications (8...
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Article
Elastinolytic activity of alveolar macrophages in smoking-associated pulmonary emphysema
Current concepts of pathomechanisms leading to acquired emphysema suggest that alveolar macrophages (AM) activated by cigarette smoking may cause an elastase/antielastase imbalance localized to the microenviro...