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  1. Article

    Open Access

    Expression ratio of the TGFβ-inducible gene MYO10 is prognostic for overall survival of squamous cell lung cancer patients and predicts chemotherapy response

    In lung cancer a deregulation of Transforming Growth Factor-β (TGFβ) signaling has been observed. Yet, the impact of TGFβ in squamous cell carcinoma of the lung (LUSC) remained to be determined. We combined ph...

    D. Dvornikov, M. A. Schneider, S. Ohse, M. Szczygieł, I. Titkova in Scientific Reports (2018)

  2. Article

    Open Access

    Tumour cell proliferation (Ki-67) in non-small cell lung cancer: a critical reappraisal of its prognostic role

    Uncontrolled proliferation is a hallmark of malignant tumour growth. Its prognostic role in non-small cell lung cancer (NSCLC) has been investigated in numerous studies with controversial results. We aimed to ...

    A Warth, J Cortis, A Soltermann, M Meister, J Budczies in British Journal of Cancer (2014)

  3. No Access

    Article

    Survival and prognostic factors in non-small cell lung cancer patients with spinal bone metastases

    For palliative care of spinal bone metastases, stability assessment is of crucial importance. Pathological fractures, instability-related patient immobility and the extent of bone metastasis have been reported...

    H. Rief MD BSc, T. Muley, T. Bruckner, T. Welzel in Strahlentherapie und Onkologie (2014)

  4. Article

    Open Access

    Tumour-site-dependent expression profile of angiogenic factors in tumour-associated stroma of primary colorectal cancer and metastases

    Tumour-associated stroma has a critical role in tumour proliferation. Our aim was to determine a specific protein expression profile of stromal angiogenic cytokines and matrix metalloproteinases (MMPs) to iden...

    C Kahlert, M Pecqueux, N Halama, H Dienemann, T Muley in British Journal of Cancer (2014)

  5. No Access

    Article

    Epigenetic screen identifies genotype-specific promoter DNA methylation and oncogenic potential of CHRNB4

    Genome-wide association studies have highlighted three major lung cancer susceptibility regions at 15q25.1, 5p15.33 and 6p21.33. To gain insight into the possible mechanistic relevance of the genes in these re...

    D B Scherf, N Sarkisyan, H Jacobsson, R Claus, J L Bermejo, B Peil, L Gu in Oncogene (2013)

  6. No Access

    Article

    Antibodies to aquaporin-4 in non-small cell lung cancer: a study on 50 patients

    S. Jarius, A. Warth, K. P. Wandinger, P. A. Schnabel, H. Hoffmann in Neurological Sciences (2010)

  7. No Access

    Article

    Histone macroH2A isoforms predict the risk of lung cancer recurrence

    Lung cancer is the leading cause of cancer deaths. Despite optimal diagnosis and early treatment, many patients die of recurrent disease. There are no sufficiently useful biomarkers to predict the risk of tumo...

    J C Sporn, G Kustatscher, T Hothorn, M Collado, M Serrano, T Muley, P Schnabel in Oncogene (2009)

  8. No Access

    Article

    FRMD3, a novel putative tumour suppressor in NSCLC

    Lung cancer including non-small cell lung carcinoma (NSCLC) represents a leading cause of cancer death in Western countries. Yet, understanding its pathobiology to improve early diagnosis and therapeutic strat...

    D Haase, M Meister, T Muley, J Hess, S Teurich, P Schnabel, B Hartenstein in Oncogene (2007)

  9. No Access

    Chapter

    Chirurgische Therapie von Lungenmetastasen

    Im Sektionsgut der an malignen Tumoren verstorbenen Patienten findet sich bei bis zu 30% eine Metastasierung in die Lunge (Willis 1967). Gilbert und Kagan (1976) fanden bei mehr als 20% der Patienten eine Meta...

    J. Schirren, T. Muley, S. Trainer, C. Trainer in Kompendium Internistische Onkologie (2006)

  10. Article

    Open Access

    CYFRA 21-1 is a prognostic determinant in non-small-cell lung cancer: results of a meta-analysis in 2063 patients

    The purpose of this study was to determine the prognostic significance of a high pretreatment serum CYFRA 21-1 level (a cytokeratin 19 fragment) adjusted for the effects of well-known co-variables in non-small...

    J-L Pujol, O Molinier, W Ebert, J-P Daurès, F Barlesi in British Journal of Cancer (2004)

  11. No Access

    Chapter

    Tumor-Marker — Bedeutung für Diagnostik und Verlaufskontrolle

    Tumor-Marker sind Substanzen, deren Auftreten bzw. erhöhte Konzentration in Körperflüssigkeiten (humorale Tumormarker) oder verstärkte zelluläre Expression (zelluläre Tumormarker) Rückschlüsse aufdas Vorliegen...

    W. Ebert, T. Muley in Management des Lungenkarzinoms (2003)

  12. No Access

    Chapter and Conference Paper

    Wertigkeit ausgedehnter chirurgischer Resektionen in der Behandlung von Pancoast-Tumoren

    Between 1986 and 1995, 46 patients suffering from pancoast-tumors underwent surgery alone or surgery in combination with pre and/or postoperative radiotherapy. Completeness of resection (R0 in 24 cases) and media...

    Ch. Kugler, S. Schießer, T. Muley, D. Latz in Vielfalt und Einheit der Chirurgie Humanit… (1998)

  13. No Access

    Chapter and Conference Paper

    Lungenmetastasen: Tumorreduktion als onkologisches Konzept

    The principle of surgery for lung metastases is the removal of all lesions in the lung that are either visible or detectable by palpation. This may be combined with complete dissection of all ipsilateral lymph...

    H. Dienemann, H. Hoffmann, C. Trainer in Vielfalt und Einheit der Chirurgie Humanit… (1998)

  14. No Access

    Chapter

    Chirurgische Therapie der Lungenmetastasen

    Im Sektionsgut der an malignen Tumoren gestorbenen Patienten findet sich zu 30% eine Metastasierung in die Lunge (Willis 1967). Gilbert u. Kagan (1976) fanden bei mehr als 20% der Patienten eine Metastasierung...

    J. Schirren, T. Muley, P. Schneider, C. Kugler, C. Trainer, H. Bülzebruck in Thoraxtumoren (1998)

  15. No Access

    Chapter

    Tumormarker — ihre Bedeutung für Diagnostik und Verlaufskontrolle des Bronchialkarzinoms

    Unter Tumormarkern versteht man Substanzen, die bei bestehendem malignen Leiden in erhöhter Konzentration in Körperflüssigkeiten vorkommen oder verstärkt zellulär exprimiert werden.

    W. Ebert, T. Muley in Thoraxtumoren (1998)

  16. No Access

    Chapter

    Chirurgische Therapie des Bronchialkarzinoms

    Die Resektion des Bronchialkarzinoms ist die effektivste Therapieform, um den Primärtumor kurativ zu entfernen. Die Strahlentherapie auch in Kombination mit der Chemotherapie erreicht eine Palliation, und in w...

    J. Schirren, T. Muley, P. Schneider, L. Latzke, H. Bülzebruck in Thoraxtumoren (1998)

  17. No Access

    Article

    Inkomplette Resektionen bei Bronchialcarcinom: Morbidität und Prognose

    Residual tumor (R1) was proven at the proximal bronchial resection margin in 88 (3.6 %) of 2464 cases of lung cancer following lung resection and standard lymph node dissection. Postoperative complications (8...

    H. Dienemann, C. Trainer, H. Hoffmann, H. Bülzebruck, T. Muley, K. Kayser in Der Chirurg (1997)

  18. No Access

    Article

    Elastinolytic activity of alveolar macrophages in smoking-associated pulmonary emphysema

    Current concepts of pathomechanisms leading to acquired emphysema suggest that alveolar macrophages (AM) activated by cigarette smoking may cause an elastase/antielastase imbalance localized to the microenviro...

    T. Muley, M. Wiebel, V. Schulz, W. Ebert in The clinical investigator (1994)