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    Chapter

    Niemann-Pick Type C-2 Disease: Identification by Analysis of Plasma Cholestane-3β,5α,6β-Triol and Further Insight into the Clinical Phenotype

    Introduction: Niemann-Pick type C disease is a rare disorder caused by impaired intracellular lipid transport due to mutations in either the NPC1 or the NPC2 gene. Ninety-five % of NPC patients sho...

    J. Reunert, A. S. Lotz-Havla, G. Polo, F. Kannenberg, M. Fobker in JIMD Reports, Volume 23 (2015)

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    Article

    Update Pneumopathologie

    Die AG Pneumopathologie der Deutschen Gesellschaft für Pathologie (DGP) blickt erneut auf ein ereignisreiches Jahr zurück. Neben dem Herbsttreffen in Bremen im November 2012 und den Sitzungen im Rahmen der Jah...

    Prof. Dr. K. Junker, F. Länger, P. Schnabel in Der Pathologe (2013)

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    Article

    Histone macroH2A isoforms predict the risk of lung cancer recurrence

    Lung cancer is the leading cause of cancer deaths. Despite optimal diagnosis and early treatment, many patients die of recurrent disease. There are no sufficiently useful biomarkers to predict the risk of tumo...

    J C Sporn, G Kustatscher, T Hothorn, M Collado, M Serrano, T Muley, P Schnabel in Oncogene (2009)

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    Article

    FRMD3, a novel putative tumour suppressor in NSCLC

    Lung cancer including non-small cell lung carcinoma (NSCLC) represents a leading cause of cancer death in Western countries. Yet, understanding its pathobiology to improve early diagnosis and therapeutic strat...

    D Haase, M Meister, T Muley, J Hess, S Teurich, P Schnabel, B Hartenstein in Oncogene (2007)

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    Article

    Concomitant use of mirtazapine and phenytoin: a drug–drug interaction study in healthy male subjects

    Abstract

    E. Spaans, M. van den Heuvel, P. Schnabel in European Journal of Clinical Pharmacology (2002)

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    Article

    The index of pulmonary vascular disease in children with congenital heart disease: relationship to clinical and haemodynamic findings

    Objective. We asked whether a scoring system [index of pulmonary vascular disease (IPVD)] that quantifies the individual pulmonary vascular pathology would relate to postoperative survival in pat...

    M. Gorenflo, M. Ullmann, C. Sebening, K. Brockmeier, S. Hagl, H. Ulmer in Virchows Archiv (2002)

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    Article

    Ruptur eines rechtskoronaren Sinus-Valsalvae-Aneurysmas in den rechten Ventrikel

    A 23 year old male Turkish patient presented with progredient dyspnea occurring while moderate physical exercise associated with tachycardia, palpitations and intermittent retrosternal twitching which had per...

    B. Cremers, P. Schnabel, F. Kuhn-Regnier, M. Böhm in Intensivmedizin und Notfallmedizin (2000)

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    Chapter

    Fettstoffwechsel, Übergewicht und Ernährung, Diabetes

    Fettstoffwechselstörungen gehören zu den häufigsten Stoffwechselerkrankungen der westlichen Hemisphäre. Sie sind durch die Erhöhung der Plasmakonzentrationen einer oder mehrerer Lipidkomponenten definiert. Die...

    M. Böhm, F. Diet, M. Flesch, U. Laufs, G. Nickenig, P. Schnabel in Klinische Kardiologie (2000)

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    Chapter

    Weitere kardiovaskuläre Risikofaktoren

    Tabakrauch stellt eines der größten Gesundheitsrisiken der Industrienationen dar (Second Joint Task Force of European and Other Societies an Coronary Prevention 1998 zur Übersicht).

    M. Böhm, F. Diet, M. Flesch, U. Laufs, G. Nickenig, P. Schnabel in Klinische Kardiologie (2000)

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    Chapter

    Genetische und molekularbiologische Aspekte primärer Kardiomyopathien

    Die großen Fortschritte der Molekularbiologie haben einen zunehmend genauen Einblick in die Struktur und Organisation des menschlichen Genoms ermöglicht und so entscheidend zur Entwicklung einer neuen Diszipli...

    P. Schnabel, M. Böhm in Klinische Kardiologie (2000)

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    Chapter

    Arterielle Hypertonie

    Entsprechend der Definition der Weltgesundheitsorganisation liegt eine arterielle Hypertonie bei diastolischen Blutdruckwerten über 90 mmHg und bei systolischen Blutdruckwerten über 140 mmHg oder bei Einnahme ...

    M. Böhm, F. Diet, M. Flesch, U. Laufs, G. Nickenig, P. Schnabel in Klinische Kardiologie (2000)

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    Article

    Sympathetic activation in heart failure: A target of therapeutic approaches

    In heart failure, decreased cardiac output leads to a number of adaptive mechanisms. Among these, neuroendocrine activation including activation of the renin-angiotensin-aldosterone system, augmentation of va...

    P. Schnabel, M. Böhm in Zeitschrift für Kardiologie (1999)

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    Article

    Hormontherapie bei Herzinsuffizienz: Wachstumshormon und Insulin-like growth factor-I

    Herzerkrankungen stellen die häufigste Todesursache in den Industrienationen dar. Trotz erheblicher Fortschritte in der Behandlung der Herzinsuffizienz durch ACE-Hemmer und Betablocker, deren prognostisch gü...

    P. Schnabel, F. Mies, M. Böhm in Zeitschrift für Kardiologie (1999)

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    Article

    Die chirurgische Therapie des extrakraniellen Karotisaneurysmas

    Fragestellung: Aneurysmen der extrakraniellen A. carotis sind selten. Über einen 16-Jahres-Zeitraum werden Indikationen, Technik, perioperative Komplikationen und Langzeitergebnisse analysiert. Methoden: Retrosp...

    H.-H. Eckstein, T. Hupp, H. Schumacher, N. Maeder, T. Kraus, P. Schnabel in Gefässchirurgie (1998)

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    Article

    Sarcoplasmic reticulum Ca2+ATPase and phospholamban mRNA and protein levels in end-stage heart failure due to ischemic or dilated cardiomyopathy

    Abnormalities in intracellular Ca2+ handling play a crucial role in the pathogenesis of heart failure. The reduced capacity of failing human myocardium to restore low resting Ca2+ levels during diastole has been ...

    M. Flesch, R. H. G. Schwinger, P. Schnabel, F. Schiffer in Journal of Molecular Medicine (1996)

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    Article

    Role of G-proteins in altered β-adrenergic responsiveness in the failing and hypertrophied myocardium

    In the heart and other tissues, β-adrenergic desensitization occurs during treatment with catecholamines. In heart failure, a strong sympathetic activation has been observed and is the cause of β-adrenergic de...

    M. Böhm, M. Flesch, P. Schnabel in Basic Research in Cardiology (1996)

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    Article

    Mutations of signal-transducing G proteins in human disease

    Heterotrimeric guanine nucleotide binding proteins (G proteins) couple a large number of cell surface receptors to their intracellular effector molecules, such as enzymes or ion channels. Mutations of G protei...

    P. Schnabel, M. Böhm in Journal of Molecular Medicine (1995)

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    Article

    FTMS studies of sputtered metal cluster ions (IV): size-selective effects in the chemistry of Fe n + with NH3 and Pd n + with D2 or C2H4

    Fe n + and Pd n + clusters...

    M. P. Irion, A. Selinger, P. Schnabel in Zeitschrift für Physik D Atoms, Molecules … (1991)

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    Chapter and Conference Paper

    The β2-Adrenoceptor Subpopulation and Its Contribution to Force Generation in Human Ventricular Myocardium

    In the failing human heart, there is a downregulation of cardiac β-adrenoceptors (Bristow et al. 1982, 1984; Ginsburg et al. 1983; Böhm et al. 1988a). As a consequence, the positive inotropic effect of β-adren...

    M. Böhm, B. Pieske, P. Schnabel, E. Erdmann in Endocrinology of the Heart (1989)

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    Article

    Lectin target cells in human central nervous system and the pituitary gland

    Peanut lectin (PNL), Concanavalin A (Con A) and Ulex europaeus lectin I (Ulex) were chosen to map their binding sites in different regions of formalin fixed and paraffin embedded human central nervous system t...

    K. Schwechheimer, G. Weiss, P. Schnabel, P. Möller in Histochemistry (1984)

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