![Loading...](https://link.springer.com/static/c4a417b97a76cc2980e3c25e2271af3129e08bbe/images/pdf-preview/spacer.gif)
-
Chapter
Niemann-Pick Type C-2 Disease: Identification by Analysis of Plasma Cholestane-3β,5α,6β-Triol and Further Insight into the Clinical Phenotype
Introduction: Niemann-Pick type C disease is a rare disorder caused by impaired intracellular lipid transport due to mutations in either the NPC1 or the NPC2 gene. Ninety-five % of NPC patients sho...
-
Article
Update Pneumopathologie
Die AG Pneumopathologie der Deutschen Gesellschaft für Pathologie (DGP) blickt erneut auf ein ereignisreiches Jahr zurück. Neben dem Herbsttreffen in Bremen im November 2012 und den Sitzungen im Rahmen der Jah...
-
Article
Histone macroH2A isoforms predict the risk of lung cancer recurrence
Lung cancer is the leading cause of cancer deaths. Despite optimal diagnosis and early treatment, many patients die of recurrent disease. There are no sufficiently useful biomarkers to predict the risk of tumo...
-
Article
FRMD3, a novel putative tumour suppressor in NSCLC
Lung cancer including non-small cell lung carcinoma (NSCLC) represents a leading cause of cancer death in Western countries. Yet, understanding its pathobiology to improve early diagnosis and therapeutic strat...
-
Article
Concomitant use of mirtazapine and phenytoin: a drug–drug interaction study in healthy male subjects
Abstract
-
Article
The index of pulmonary vascular disease in children with congenital heart disease: relationship to clinical and haemodynamic findings
Objective. We asked whether a scoring system [index of pulmonary vascular disease (IPVD)] that quantifies the individual pulmonary vascular pathology would relate to postoperative survival in pat...
-
Article
Ruptur eines rechtskoronaren Sinus-Valsalvae-Aneurysmas in den rechten Ventrikel
A 23 year old male Turkish patient presented with progredient dyspnea occurring while moderate physical exercise associated with tachycardia, palpitations and intermittent retrosternal twitching which had per...
-
Chapter
Fettstoffwechsel, Übergewicht und Ernährung, Diabetes
Fettstoffwechselstörungen gehören zu den häufigsten Stoffwechselerkrankungen der westlichen Hemisphäre. Sie sind durch die Erhöhung der Plasmakonzentrationen einer oder mehrerer Lipidkomponenten definiert. Die...
-
Chapter
Weitere kardiovaskuläre Risikofaktoren
Tabakrauch stellt eines der größten Gesundheitsrisiken der Industrienationen dar (Second Joint Task Force of European and Other Societies an Coronary Prevention 1998 zur Übersicht).
-
Chapter
Genetische und molekularbiologische Aspekte primärer Kardiomyopathien
Die großen Fortschritte der Molekularbiologie haben einen zunehmend genauen Einblick in die Struktur und Organisation des menschlichen Genoms ermöglicht und so entscheidend zur Entwicklung einer neuen Diszipli...
-
Chapter
Arterielle Hypertonie
Entsprechend der Definition der Weltgesundheitsorganisation liegt eine arterielle Hypertonie bei diastolischen Blutdruckwerten über 90 mmHg und bei systolischen Blutdruckwerten über 140 mmHg oder bei Einnahme ...
-
Article
Sympathetic activation in heart failure: A target of therapeutic approaches
In heart failure, decreased cardiac output leads to a number of adaptive mechanisms. Among these, neuroendocrine activation including activation of the renin-angiotensin-aldosterone system, augmentation of va...
-
Article
Hormontherapie bei Herzinsuffizienz: Wachstumshormon und Insulin-like growth factor-I
Herzerkrankungen stellen die häufigste Todesursache in den Industrienationen dar. Trotz erheblicher Fortschritte in der Behandlung der Herzinsuffizienz durch ACE-Hemmer und Betablocker, deren prognostisch gü...
-
Article
Die chirurgische Therapie des extrakraniellen Karotisaneurysmas
Fragestellung: Aneurysmen der extrakraniellen A. carotis sind selten. Über einen 16-Jahres-Zeitraum werden Indikationen, Technik, perioperative Komplikationen und Langzeitergebnisse analysiert. Methoden: Retrosp...
-
Article
Sarcoplasmic reticulum Ca2+ATPase and phospholamban mRNA and protein levels in end-stage heart failure due to ischemic or dilated cardiomyopathy
Abnormalities in intracellular Ca2+ handling play a crucial role in the pathogenesis of heart failure. The reduced capacity of failing human myocardium to restore low resting Ca2+ levels during diastole has been ...
-
Article
Role of G-proteins in altered β-adrenergic responsiveness in the failing and hypertrophied myocardium
In the heart and other tissues, β-adrenergic desensitization occurs during treatment with catecholamines. In heart failure, a strong sympathetic activation has been observed and is the cause of β-adrenergic de...
-
Article
Mutations of signal-transducing G proteins in human disease
Heterotrimeric guanine nucleotide binding proteins (G proteins) couple a large number of cell surface receptors to their intracellular effector molecules, such as enzymes or ion channels. Mutations of G protei...
-
Article
FTMS studies of sputtered metal cluster ions (IV): size-selective effects in the chemistry of Fe n + with NH3 and Pd n + with D2 or C2H4
Fe n + and Pd n + clusters...
-
Chapter and Conference Paper
The β2-Adrenoceptor Subpopulation and Its Contribution to Force Generation in Human Ventricular Myocardium
In the failing human heart, there is a downregulation of cardiac β-adrenoceptors (Bristow et al. 1982, 1984; Ginsburg et al. 1983; Böhm et al. 1988a). As a consequence, the positive inotropic effect of β-adren...
-
Article
Lectin target cells in human central nervous system and the pituitary gland
Peanut lectin (PNL), Concanavalin A (Con A) and Ulex europaeus lectin I (Ulex) were chosen to map their binding sites in different regions of formalin fixed and paraffin embedded human central nervous system t...