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  1. Article

    Open Access

    The gastrin and cholecystokinin receptors mediated signaling network: a scaffold for data analysis and new hypotheses on regulatory mechanisms

    The gastrointestinal peptide hormones cholecystokinin and gastrin exert their biological functions via cholecystokinin receptors CCK1R and CCK2R respectively. Gastrin, a central regulator of gastric acid secre...

    Sushil Tripathi, Åsmund Flobak, Konika Chawla, Anaïs Baudot in BMC Systems Biology (2015)

  2. Article

    Open Access

    Finding gene regulatory network candidates using the gene expression knowledge base

    Network-based approaches for the analysis of large-scale genomics data have become well established. Biological networks provide a knowledge scaffold against which the patterns and dynamics of ‘omics’ data can be...

    Aravind Venkatesan, Sushil Tripathi, Alejandro Sanz de Galdeano in BMC Bioinformatics (2014)

  3. Article

    Open Access

    The duration of gastrin treatment affects global gene expression and molecular responses involved in ER stress and anti-apoptosis

    How cells decipher the duration of an external signal into different transcriptional outcomes is poorly understood. The hormone gastrin can promote a variety of cellular responses including proliferation, diff...

    Linn-Karina M Selvik, Christina S Fjeldbo, Arnar Flatberg in BMC Genomics (2013)