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The 1+Million Genomes Minimal Dataset for Cancer
Defining minimal standards for data collection is key to creating interoperative, searchable genomic and clinical databases. We highlight here the 1+Million Genomes Minimal Dataset for Cancer, encompassing 140...
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Open AccessSystematic review: predictive value of organoids in colorectal cancer
While chemotherapy alone or in combination with radiotherapy and surgery are important modalities in the treatment of colorectal cancer, their widespread use is not paired with an abundance of diagnostic tools...
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Article
Open AccessCorrection to: Improving public cancer care by implementing precision medicine in Norway: IMPRESS-Norway
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Open AccessImproving public cancer care by implementing precision medicine in Norway: IMPRESS-Norway
Matching treatment based on tumour molecular characteristics has revolutionized the treatment of some cancers and has given hope to many patients. Although personalized cancer care is an old concept, renewed a...
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A national precision cancer medicine implementation initiative for Norway
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Open AccessAuthor Correction: High-throughput screening reveals higher synergistic effect of MEK inhibitor combinations in colon cancer spheroids
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Open AccessHigh-throughput screening reveals higher synergistic effect of MEK inhibitor combinations in colon cancer spheroids
Drug combinations have been proposed to combat drug resistance, but putative treatments are challenged by low bench-to-bed translational efficiency. To explore the effect of cell culture format and readout met...
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Open AccessA high-throughput drug combination screen of targeted small molecule inhibitors in cancer cell lines
While there is a high interest in drug combinations in cancer therapy, openly accessible datasets for drug combination responses are sparse. Here we present a dataset comprising 171 pairwise combinations of 19...
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Article
Open AccessThe gastrin and cholecystokinin receptors mediated signaling network: a scaffold for data analysis and new hypotheses on regulatory mechanisms
The gastrointestinal peptide hormones cholecystokinin and gastrin exert their biological functions via cholecystokinin receptors CCK1R and CCK2R respectively. Gastrin, a central regulator of gastric acid secre...
