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Article
Open AccessJoint changes in RNA, RNA polymerase II, and promoter activity through the cell cycle identify non-coding RNAs involved in proliferation
Proper regulation of the cell cycle is necessary for normal growth and development of all organisms. Conversely, altered cell cycle regulation often underlies proliferative diseases such as cancer. Long non-co...
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Article
Open AccessComprehensive transcriptomic analyses of tissue, serum, and serum exosomes from hepatocellular carcinoma patients
The expression of microRNAs (miRNAs) is a promising prognostic and diagnostic tool in hepatocellular carcinoma (HCC). Here we performed small RNA sequencing (sRNA-seq) of tissue, serum and serum exosomes to in...
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Article
Open AccessThe gastrin and cholecystokinin receptors mediated signaling network: a scaffold for data analysis and new hypotheses on regulatory mechanisms
The gastrointestinal peptide hormones cholecystokinin and gastrin exert their biological functions via cholecystokinin receptors CCK1R and CCK2R respectively. Gastrin, a central regulator of gastric acid secre...
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Article
Open AccessZifBASE: a database of zinc finger proteins and associated resources
Information on the occurrence of zinc finger protein motifs in genomes is crucial to the develo** field of molecular genome engineering. The knowledge of their target DNA-binding sequences is vital to develo...
