-
Article
Open AccessA multiomics disease progression signature of low-risk ccRCC
Clear cell renal cell carcinoma (ccRCC) is the most common renal cancer. Identification of ccRCC likely to progress, despite an apparent low risk at the time of surgery, represents a key clinical issue. From a...
-
Article
Open AccessAGAP2-AS1 as a prognostic biomarker in low-risk clear cell renal cell carcinoma patients with progressing disease
Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cancer and one of the most common cancers. While survival for localized ccRCC is good, the survival of metastatic disease is not, and...
-
Article
Open AccessIncreased protein intake affects pro-opiomelanocortin (POMC) processing, immune function and IGF signaling in peripheral blood mononuclear cells of home-dwelling old subjects using a genome-wide gene expression approach
Adequate protein intake among older adults is associated with better health outcomes such as immune function and metabolic regulation of skeletal muscle, but conflicting results make it difficult to define the...
-
Article
Open AccessFine needle aspirates of kidneys: a promising tool for RNA sequencing in native and transplanted kidneys
Transcriptome analysis is emerging as emerging as a promising tool to enhance precision of diagnosis and monitoring in solid organ transplantation. Clinical progress has however been hampered by the current re...
-
Article
Identification of dorsal–ventral hippocampal differentiation in neonatal rats
The adult hippocampal formation (HF) is functionally, connectionally, and transcriptionally differentiated along the dorsal–ventral axis. At birth, the hippocampus appears shortened along its dorsal–ventral ax...
-
Article
Open AccessIntracellular growth of Mycobacterium avium subspecies and global transcriptional responses in human macrophages after infection
Mycobacterium avium subsp. avium (Maa) and M. avium subsp. hominissuis (Mah) are environmental mycobacteria and significant opportunistic pathogens. Mycobacterium avium infections in humans and pigs are mainly du...
-
Article
Open AccessThe duration of gastrin treatment affects global gene expression and molecular responses involved in ER stress and anti-apoptosis
How cells decipher the duration of an external signal into different transcriptional outcomes is poorly understood. The hormone gastrin can promote a variety of cellular responses including proliferation, diff...
-
Article
Open AccessA framework for significance analysis of gene expression data using dimension reduction methods
The most popular methods for significance analysis on microarray data are well suited to find genes differentially expressed across predefined categories. However, identification of features that correlate wit...
