4 Result(s)
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Article
Open AccessResults and lessons learned from the sbv IMPROVER metagenomics diagnostics for inflammatory bowel disease challenge
A growing body of evidence links gut microbiota changes with inflammatory bowel disease (IBD), raising the potential benefit of exploiting metagenomics data for non-invasive IBD diagnostics. The sbv IMPROVER m...
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Article
Open AccessComprehensive systems biology analysis of a 7-month cigarette smoke inhalation study in C57BL/6 mice
Smoking of combustible cigarettes has a major impact on human health. Using a systems toxicology approach in a model of chronic obstructive pulmonary disease (C57BL/6 mice), we assessed the health consequences...
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Article
Open AccessThe species translation challenge—A systems biology perspective on human and rat bronchial epithelial cells
The biological responses to external cues such as drugs, chemicals, viruses and hormones, is an essential question in biomedicine and in the field of toxicology, and cannot be easily studied in humans. Thus, b...
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Article
Recapitulation of premature ageing with iPSCs from Hutchinson–Gilford progeria syndrome
The premature ageing disorder Hutchinson–Gilford progeria syndrome (HGPS) is a rare genetic condition characterized by a rapid onset of signs associated with normal ageing, such as atherosclerosis and the dege...
