-
Article
Open AccessEarly noninvasive prenatal paternity testing by targeted fetal DNA analysis
Today the challenge in paternity testing is to provide an accurate noninvasive assay that can be performed early during pregnancy. This requires the use of novel analytical methods capable of detecting the low...
-
Article
Open AccessFurther insight into the global variability of the OCA2-HERC2 locus for human pigmentation from multiallelic markers
The OCA2-HERC2 locus is responsible for the greatest proportion of eye color variation in humans. Numerous studies extensively described both functional SNPs and associated patterns of variation over this region....
-
Article
Open AccessComprehensive systems biology analysis of a 7-month cigarette smoke inhalation study in C57BL/6 mice
Smoking of combustible cigarettes has a major impact on human health. Using a systems toxicology approach in a model of chronic obstructive pulmonary disease (C57BL/6 mice), we assessed the health consequences...
-
Article
SAS-6 defines a protein family required for centrosome duplication in C. elegans and in human cells
The mechanisms that ensure centrosome duplication are poorly understood. In Caenorhabditis elegans, ZYG-1, SAS-4, SAS-5 and SPD-2 are required for centriole formation. However, it is unclear whether these protein...
-
Article
Centriolar SAS-5 is required for centrosome duplication in C. elegans
Centrosomes, the major microtubule-organizing centres (MTOCs) of animal cells, are comprised of a pair of centrioles surrounded by pericentriolar material (PCM). Early in the cell cycle, there is a single cent...
