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Article
Nucleus segmentation of white blood cells in blood smear images by modeling the pixels’ intensities as a set of three Gaussian distributions
The precise segmentation of white blood cells (WBCs) within blood smear images is a significant challenge with implications for both medical research and image processing. Of particular importance is the often...
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Article
The homeobox transcription factor DUXBL controls exit from totipotency
In mice, exit from the totipotent two-cell (2C) stage embryo requires silencing of the 2C-associated transcriptional program. However, the molecular mechanisms involved in this process remain poorly understood...
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Article
Open AccessCTCF is a barrier for 2C-like reprogramming
Totipotent cells have the ability to generate embryonic and extra-embryonic tissues. Interestingly, a rare population of cells with totipotent-like potential, known as 2 cell (2C)-like cells, has been identifi...
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Article
TRF2-mediated telomere protection is dispensable in pluripotent stem cells
In mammals, telomere protection is mediated by the essential protein TRF2, which binds chromosome ends and ensures genome integrity1,2. TRF2 depletion results in end-to-end chromosome fusions in all cell types th...
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Article
Author Correction: Conversion of human fibroblasts to angioblast-like progenitor cells
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessCell surface GRP78 promotes stemness in normal and neoplastic cells
Reliable approaches to identify stem cell mechanisms that mediate aggressive cancer could have great therapeutic value, based on the growing evidence of embryonic signatures in metastatic cancers. However, how...
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Article
Damage assessment of the 2015 Mw 8.3 Illapel earthquake in the North-Central Chile
Destructive megathrust earthquakes, such as the 2015 Mw 8.3 Illapel event, frequently affect Chile. In this study, we assess the damage of the 2015 Illapel Earthquake in the Coquimbo Region (North-Central Chil...
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Article
Near-Field Spectra of Large Earthquakes
We have studied the spectra of large subduction earthquakes in Chile at short epicentral distances. In this work, we concentrate on the Mw 8.2, Iquique earthquake of 1 April 2014. For such a large event, in most ...
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Chapter and Conference Paper
A Hybrid Reinforcement Learning and Cellular Automata Model for Crowd Simulation on the GPU
We present a GPU-based hybrid model for crowd simulations. The model uses reinforcement learning to guide groups of pedestrians towards a goal while adapting to environmental dynamics, and a cellular automaton...
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Article
Reduction of the surface colour variability of thermally modified Eucalyptus globulus wood by colour pre-grading and homogeneity thermal treatment
A new method that consists of combining wood pre-grading by surface colour followed by the application of homogeneity thermal treatments is proposed to reduce the surface colour variability of the thermally mo...
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Chapter and Conference Paper
Contrast Enhancement of RGB Color Images by Histogram Equalization of Color Vectors’ Intensities
The histogram equalization (HE) is a technique developed for image contrast enhancement of grayscale images. For RGB (Red, Green, Blue) color images, the HE is usually applied in the color channels separately...
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Article
Ground motion prediction equations for the Chilean subduction zone
The Chilean subduction zone is one of the most active in the world. Six events of magnitude greater than \(M_w = 7.5\) ...
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Chapter and Conference Paper
Assigning-Tasks Method for Developers in Software Projects Using up Similarity Coefficients
In the Software industry, big software projects are carried out with hundreds of developers. The fast change in technologies and development environments increase the complexity. Usually, there are project te...
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Article
Earthquake dynamics on circular faults: a review 1970–2015
We review the development of earthquake dynamics taken from the point of view of the origin of seismic radiation instead of the detailed study of rupture propagation on complex surfaces. Many features of seism...
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Article
Diversity of the 2014 Iquique’s foreshocks and aftershocks: clues about the complex rupture process of a Mw 8.1 earthquake
We study the foreshocks and aftershocks of the 1 April 2014 Iquique earthquake of Mw 8.1. Most of these events were recorded by a large digital seismic network that included the Northern Chile permanent networ...
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Chapter and Conference Paper
Computing the Number of Groups for Color Image Segmentation Using Competitive Neural Networks and Fuzzy C-Means
Fuzzy C-means (FCM) is one of the most often techniques employed for color image segmentation; the drawback with this technique is the number of clusters the data, pixels’ colors, is grouped must be defined a...
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Article
Open AccessLimiting replication stress during somatic cell reprogramming reduces genomic instability in induced pluripotent stem cells
The generation of induced pluripotent stem cells (iPSC) from adult somatic cells is one of the most remarkable discoveries in recent decades. However, several works have reported evidence of genomic instabilit...
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Article
Open AccessScalable efficient expansion of mesenchymal stem cells in xeno free media using commercially available reagents
The rapid clinical translation of mesenchymal stem cells (MSC) has resulted in the development of cell-based strategies for multiple indications. Unfortunately one major barrier to widespread implementation of...
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Chapter and Conference Paper
Color Characterization Comparison for Machine Vision-Based Fruit Recognition
In this paper we present a comparison between three color characterizations methods applied for fruit recognition, two of them are selected from two related works and the third is the authors’ proposal; in the...
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Article
Modelling Fanconi anemia pathogenesis and therapeutics using integration-free patient-derived iPSCs
Fanconi anaemia (FA) is a recessive disorder characterized by genomic instability, congenital abnormalities, cancer predisposition and bone marrow (BM) failure. However, the pathogenesis of FA is not fully und...
