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  1. Article

    Open Access

    Bladder cancer organoids as a functional system to model different disease stages and therapy response

    Bladder Cancer (BLCa) inter-patient heterogeneity is the primary cause of treatment failure, suggesting that patients could benefit from a more personalized treatment approach. Patient-derived organoids (PDOs)...

    Martina Minoli, Thomas Cantore, Daniel Hanhart, Mirjam Kiener… in Nature Communications (2023)

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  2. Article

    Open Access

    Patient-derived xenografts and organoids model therapy response in prostate cancer

    Therapy resistance and metastatic processes in prostate cancer (PCa) remain undefined, due to lack of experimental models that mimic different disease stages. We describe an androgen-dependent PCa patient-deri...

    Sofia Karkampouna, Federico La Manna, Andrej Benjak, Mirjam Kiener… in Nature Communications (2021)

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  3. Article

    Open Access

    Verteporfin-induced lysosomal compartment dysregulation potentiates the effect of sorafenib in hepatocellular carcinoma

    Lysosomal sequestration of anti-cancer compounds reduces drug availability at intracellular target sites, thereby limiting drug-sensitivity and inducing chemoresistance. For hepatocellular carcinoma (HCC), sor...

    Jacopo Gavini, Noëlle Dommann, Manuel O. Jakob, Adrian Keogh… in Cell Death & Disease (2019)

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  4. No Access

    Article

    Inhibition of TGFβ type I receptor activity facilitates liver regeneration upon acute CCl4 intoxication in mice

    Liver exhibits a remarkable maintenance of functional homeostasis in the presence of a variety of damaging toxic factors. Tissue regeneration involves cell replenishment and extracellular matrix remodeling. K...

    Sofia Karkampouna, Marie-José Goumans, Peter ten Dijke… in Archives of Toxicology (2016)