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Article

Verteporfin-induced lysosomal compartment dysregulation potentiates the effect of sorafenib in hepatocellular carcinoma

Lysosomal sequestration of anti-cancer compounds reduces drug availability at intracellular target sites, thereby limiting drug-sensitivity and inducing chemoresistance. For hepatocellular carcinoma (HCC), sor...

Jacopo Gavini, Noëlle Dommann, Manuel O. Jakob, Adrian Keogh… in Cell Death & Disease (2019)