-
Article
Open AccessDifferent photosynthetic responses of haploid and diploid Emiliania huxleyi (Prymnesiophyceae) to high light and ultraviolet radiation
Solar radiation varies quantitatively and qualitatively while penetrating through the seawater column and thus is one of the most important environmental factors sha** the vertical distribution pattern of ph...
-
Article
PD-1 signaling facilitates activation of lymphoid tissue inducer cells by restraining fatty acid oxidation
Anti-programmed death-1 (PD-1) immunotherapy that aims to restore T cell activity in cancer patients frequently leads to immune-related adverse events such as colitis. However, the underlying mechanism is stil...
-
Article
Open AccessCAF promotes chemoresistance through NRP2 in gastric cancer
Fibroblasts are the predominant cell type in the stroma of tumor, and cancer-associated fibroblasts (CAFs) promote cancer chemoresistance by secreting various bioactive molecules. However, the differential exp...
-
Article
The CBS-H2S axis promotes liver metastasis of colon cancer by upregulating VEGF through AP-1 activation
The main therapy for colon cancer with liver metastasis is chemotherapy based on 5-fluorouracil combined with targeted drugs. However, acquired drug resistance and severe adverse reactions limit patients’ bene...
-
Article
The environmental adaptability and reproductive properties of invasive green alga Codium fragile from the Nan’ao Island, South China Sea
It has been widely recognized that biological invasion has become one of the greatest threats to the ecosystem. Codium fragile is an invasive species which exhibits a variety of attributes like parthenogenesis, w...
-
Article
Open AccessOverexpression of CBS/H2S inhibits proliferation and metastasis of colon cancer cells through downregulation of CD44
The role of hydrogen sulfide (H2S) in cancer biology is controversial, including colorectal cancer. The bell-shaped effect of H2S refers to pro-cancer action at lower doses and anti-cancer effect at higher concen...
-
Article
The Relationship of Morphological-Hemodynamic Characteristics, Inflammation, and Remodeling of Aneurysm Wall in Unruptured Intracranial Aneurysms
Aneurysm wall remodeling (AWR) is an important pathological characteristic in aneurysm wall, which was characterized by abnormal histological structure and inflammation infiltration. In the present study, the ...
-
Article
Multidimensional predicting model of intracranial aneurysm stability with backpropagation neural network: a preliminary study
The stability of intracranial aneurysms (IAs) may involve in multidimensional factors. Backpropagation (BP) neural network could be adopted to support clinical work. This preliminary study aimed to delve into ...
-
Article
A scoring system to discriminate blood blister-like aneurysms: a multidimensional study using patient-specific model
Presurgical discrimination of blood blister-like aneurysms (BBAs) can assist neurosurgeons in clinical decision-making. The aim of this study was to investigate the characteristics of BBAs and construct a usef...
-
Article
Cochlear implantation in prelingually deaf children with white matter lesions
White matter lesions (WMLs) are the most common central nervous system changes observed during cochlear implant evaluation. However, its clinical significance in cochlear implantation (CI) remains unclear. The...
-
Article
Open AccessSupraclinoid internal carotid artery blister-like aneurysms: hypothesized pathogenesis and microsurgical clip** outcomes
Blister-like aneurysms (BLAs) on the supraclinoid segment of the internal carotid artery (ICA) are an enigma of cerebrovascular disease. Neither has a definite pathogenesis been so far identified, nor have uni...
-
Article
Open AccessSurgical treatment for antiplatelet intracerebral hemorrhage (SAP-ICH): protocol for a prospective cohort study of emergency surgery for severe spontaneous intracerebral hemorrhage patients on long-term oral antiplatelet treatment
Despite the capability of emergency surgery to reduce the mortality of severe spontaneous intracranial hemorrhage (SSICH) patients, the effect and safety of surgical treatment for severe spontaneous intracrani...
-
Chapter
Microalgae Continuous and Semi-continuous Cultures
For many studies using microalgae as research subjects, culture methodology is a key part that influences results. There are many advantages to using continuous or semicontinuous cultures compared to batch cul...
-
Article
Myringotomy and tube insertion combined with balloon eustachian tuboplasty for the treatment of otitis media with effusion in children
This study aimed to clarify the role and safety of balloon eustachian tuboplasty (BET) in the treatment of otitis media with effusion (OME) in children.
-
Article
Open AccessThe novel long noncoding RNA CRART16 confers cetuximab resistance in colorectal cancer cells by enhancing ERBB3 expression via miR-371a-5p
Long noncoding RNAs (lncRNAs) have been shown to participate in multiple biological processes and confer drug resistance. However, it remains unclear whether lncRNAs are involved in conferring cetuximab resist...
-
Article
Tissue-specific transcription reprogramming promotes liver metastasis of colorectal cancer
Metastasis, the development of secondary malignant growths at a distance from a primary tumor, is the cause of death for 90% of cancer patients, but little is known about how metastatic cancer cells adapt to a...
-
Article
Open AccessLow expression of SPARC in gastric cancer-associated fibroblasts leads to stemness transformation and 5-fluorouracil resistance in gastric cancer
The aim of the present study was to clarify the correlations between SPARC expression in gastric cancer-associated fibroblasts (GCAFs) and the prognosis of patients with gastric cancer and to elucidate the rol...
-
Article
Lymph node dissection could bring survival benefits to patients diagnosed with clinically node-negative upper urinary tract urothelial cancer: a population-based, propensity score-matched study
To evaluate the survival benefits that lymph node dissection (LND) brought to clinically node-negative upper tract urothelial carcinoma (UTUC) patients.
-
Article
Transoral vestibule approach for thyroid disease: a systematic review
Transoral endoscopic/robotic thyroidectomy vestibule approach (TOETVA/TORTVA) is a novel technology that has been proposed for the treatment of thyroid disease. Its adoption has increased because of its satisf...
-
Article
Open AccessActivated gastric cancer-associated fibroblasts contribute to the malignant phenotype and 5-FU resistance via paracrine action in gastric cancer
Cancer-associated fibroblasts (CAFs) play important roles in tumor progression. However, the behaviors of activated CAFs in gastric cancer remain to be determined. The aim of the present study was to investiga...
