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Article
Open AccessSTEAP2 promotes hepatocellular carcinoma progression via increased copper levels and stress-activated MAP kinase activity
Six Transmembrane Epithelial Antigen of Prostate 2 (STEAP2) belongs to a family of metalloreductases, which indirectly aid in uptake of iron and copper ions. Its role in hepatocellular carcinoma (HCC) remains ...
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Article
Open AccessHM_ADET: a hybrid model for automatic detection of eyelid tumors based on photographic images
The accurate detection of eyelid tumors is essential for effective treatment, but it can be challenging due to small and unevenly distributed lesions surrounded by irrelevant noise. Moreover, early symptoms of...
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Article
Open AccessNeonatal IL-4 Over-Exposure is Accompanied by Macrophage Accumulation in Dura Mater After Instant Anti-inflammatory Cytokine Response in CSF
Multiple studies have shown that clinical events resulting into neonatal IL-4 over-exposure, such as asthma in early life and food allergy, were associated with brain damage and that the neuroinflammation indu...
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Article
Swell1 channel-mediated tonic GABA release from astrocytes modulates cocaine reward
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Open AccessMechanism of thermoviscoelasticity driven solid-liquid interface reducing friction for polymer alloy coating
High-temperature ablation is a common failure phenomenon that limits the service life of the transmission parts on heavy-duty machines used in heavy load, high temperature, high shock conditions due to in-suff...
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Article
Structure, Function and Distribution of ATP8A2 in Human and Mice
ATP8A2 can translocate phospholipids from exoplasmic to the cytoplasmic leaflets to establish and maintain the lipid asymmetry between the two leaflets. ATP8A2 has been recently reported due to the patients po...
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Article
Open AccessSouth Asian black carbon is threatening the water sustainability of the Asian Water Tower
Long-range transport of black carbon from South Asia to the Tibetan plateau and its deposition on glaciers directly enhances glacier melt. Here we find South Asian black carbon also has an indirect effect on t...
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Article
Influence of South Asian Biomass Burning on Ozone and Aerosol Concentrations Over the Tibetan Plateau
In this work, the influence of South Asian biomass burning emissions on O3 and PM2.5 concentrations over the Tibetan Plateau (TP) is investigated by using the regional climate chemistry transport model WRF-Chem. ...
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Article
Macamide B Pretreatment Attenuates Neonatal Hypoxic-Ischemic Brain Damage of Mice Induced Apoptosis and Regulates Autophagy via the PI3K/AKT Signaling Pathway
Lepidium meyenii (maca) is an annual or biennial herb from South America that is a member of the genus Lepidium L. in the family Cruciferae. This herb possesses antioxidant and antiapoptotic activities, enhances ...
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Article
Aspirin does not affect hematoma growth in severe spontaneous intracranial hematoma
Hematoma growth (HG) affects the prognosis of patients with spontaneous intracranial hematoma (ICH), but there is still a lack of evidence about the effects of aspirin (acetylsalicylic acid, ASA) on HG in pati...
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A nomogram to predict the risk of postoperative intracranial rebleeding in patients with spontaneous intracranial hematoma
The 30-day mortality rate of spontaneous cerebral hemorrhage (ICH) is approximately 30–50%. Surgery may improve the prognosis of patients with severe ICH. However, ICH survivors after surgery still face the ri...
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Article
The Relationship of Morphological-Hemodynamic Characteristics, Inflammation, and Remodeling of Aneurysm Wall in Unruptured Intracranial Aneurysms
Aneurysm wall remodeling (AWR) is an important pathological characteristic in aneurysm wall, which was characterized by abnormal histological structure and inflammation infiltration. In the present study, the ...
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Article
Multidimensional predicting model of intracranial aneurysm stability with backpropagation neural network: a preliminary study
The stability of intracranial aneurysms (IAs) may involve in multidimensional factors. Backpropagation (BP) neural network could be adopted to support clinical work. This preliminary study aimed to delve into ...
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A nomogram to predict the risk of early postoperative ischemic events in patients with spontaneous intracranial hematoma
Spontaneous intracranial hematoma (ICH) is the second leading cause of stroke and has a high risk of postoperative ischemic events (PIEs). But, the evidence on PIEs in ICH patients still lacks. Therefore, a re...
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Emergency surgery is an effective way to improve the outcome of severe spontaneous intracerebral hemorrhage patients on long-term oral antiplatelet therapy
The necessity of emergency surgery for severe spontaneous intracerebral hemorrhage (SSICH) patients on long-term oral antiplatelet therapy (LOAPT) remains unclear. The aim of this study was to investigate the ...
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Article
Can summer monsoon moisture invade the Jade Pass in Northwestern China?
Heavy precipitation events are increasingly concerned because their significant contribution to annual precipitation in the Northwestern China, which might be related to invasion of summer monsoon moisture. It...
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Article
Open AccessPrenatal influenza vaccination rescues impairments of social behavior and lamination in a mouse model of autism
Prenatal infection is a substantial risk factor for neurodevelopmental disorders such as autism in offspring. We have previously reported that influenza vaccination (VAC) during early pregnancy contributes to ...
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Article
Improved Land Use and Leaf Area Index Enhances WRF-3DVAR Satellite Radiance Assimilation: A Case Study Focusing on Rainfall Simulation in the Shule River Basin during July 2013
The application of satellite radiance assimilation can improve the simulation of precipitation by numerical weather prediction models. However, substantial quantities of satellite data, especially those derive...
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Article
Open AccessReduced Graphene Oxide-Gold Nanoparticle Nanoframework as a Highly Selective Separation Material for Aflatoxins
Graphene-based materials have been studied in many applications, owing to the excellent electrical, mechanical, and thermal properties of graphene. In the current study, an environmentally friendly approach to...
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Potential feedback between aerosols and meteorological conditions in a heavy pollution event over the Tibetan Plateau and Indo-Gangetic Plain
A regional climate model, WRF-Chem, was used to investigate the feedback between aerosols and meteorological conditions in the planetary boundary layer (PBL) over the Tibetan Plateau (TP) and Indo-Gangetic Pla...
