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  1. Article

    Open Access

    IL-21R-STAT3 signalling initiates a differentiation program in uterine tissue-resident NK cells to support pregnancy

    Tissue-resident Natural Killer (trNK) cells are crucial components of local immunity that activate rapidly upon infection. However, under steady state conditions, their responses are tightly controlled to prev...

    Mengwei Han, Luni Hu, Di Wu, Yime Zhang, Peng Li, **ngyu Zhao… in Nature Communications (2023)

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  2. No Access

    Article

    Proline uptake promotes activation of lymphoid tissue inducer cells to maintain gut homeostasis

    Metabolic regulation is integral to the proper functioning of innate lymphoid cells, yet the underlying mechanisms remain elusive. Here, we show that disruption of exogenous proline uptake, either through diet...

    Di Wu, Zongxian Li, Yime Zhang, Yinlian Zhang, Guanqun Ren, Yanyu Zeng… in Nature Metabolism (2023)

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    Article

    PD-1 signaling facilitates activation of lymphoid tissue inducer cells by restraining fatty acid oxidation

    Anti-programmed death-1 (PD-1) immunotherapy that aims to restore T cell activity in cancer patients frequently leads to immune-related adverse events such as colitis. However, the underlying mechanism is stil...

    Di Wu, Luni Hu, Mengwei Han, Yichen Deng, Yime Zhang, Guanqun Ren… in Nature Metabolism (2022)