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Article
Open AccessEffects of acute heat stress on protein expression and histone modification in the adrenal gland of male layer-type country chickens
The adrenal gland responds to heat stress by epinephrine and glucocorticoid release to alleviate the adverse effects. This study investigated the effect of acute heat stress on the protein profile and histone ...
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Article
Open AccessCombination of dextromethorphan and memantine in treating bipolar spectrum disorder: a 12-week double-blind randomized clinical trial
The aim of this study is to determine whether adding combination of agents with anti-inflammatory and neurotrophic effects is more efficacious than mood stabilizer alone in improving clinical symptoms, plasma ...
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Article
Anti-herpetic Medications and Reduced Risk of Dementia in Patients with Herpes Simplex Virus Infections—a Nationwide, Population-Based Cohort Study in Taiwan
This retrospective cohort study is to investigate the association between herpes simplex virus (HSV) infections and dementia, and the effects of anti-herpetic medications on the risk involved, using Taiwan’s N...
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Article
Novelty seeking mediates the effect of DRD3 variation on onset age of amphetamine dependence in Han Chinese population
The dopamine receptor D3 (DRD3) gene, one of the candidate genes for amphetamine dependence (AD), is involved in the mesolimbic dopaminergic system, implicated as the underlying mechanism of addiction. Our case–c...
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Article
Open AccessFunctional genomics study of acute heat stress response in the small yellow follicles of layer-type chickens
This study investigated global gene and protein expression in the small yellow follicle (SYF; 6–8 mm in diameter) tissues of chickens in response to acute heat stress. Twelve 30-week-old layer-type hens were d...
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Article
Open AccessThe correlation between plasma brain-derived neurotrophic factor and cognitive function in bipolar disorder is modulated by the BDNF Val66Met polymorphism
We explored the effect of the Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism (rs6265) on correlation between changes in plasma BDNF levels with cognitive function and quality of life (QoL) after 1...
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Article
Open AccessAssociation of neuropeptide Y promoter polymorphism (rs16147) with perceived stress and cardiac vagal outflow in humans
Neuropeptide Y (NPY) is involved in resilience to stress and higher vagal (parasympathetic) activity has been associated with greater stress resilience. Thus, we examined whether rs16147, a functional promoter po...
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Article
Open AccessComparing clinical responses and the biomarkers of BDNF and cytokines between subthreshold bipolar disorder and bipolar II disorder
Patients with subthreshold hypomania (SBP; subthreshold bipolar disorder) were indistinguishable from those with bipolar disorder (BP)-II on clinical bipolar validators, but their analyses lacked biological an...
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Article
Open AccessFunctional Ser205Leu polymorphism of the nerve growth factor receptor (NGFR) gene is associated with vagal autonomic dysregulation in humans
Evidence indicates that reduced cardiac vagal (parasympathetic) tone, a robust cardiovascular risk factor, is a trait vulnerability marker of major depressive disorder (MDD). The Ser205/Ser205 genotype of the fun...
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Article
Dopamine transporter gene may be associated with bipolar disorder and its personality traits
Dopamine transporter and its genetic factors have been suggested to play a critical role in the development of bipolar disorder (BPD). However, the importance of the dopamine transporter gene (DAT1) in the pathog...
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Article
Open AccessLow-dose memantine attenuated methadone dose in opioid-dependent patients: a 12-week double-blind randomized controlled trial
Low-dose memantine might have anti-inflammatory and neurotrophic effects mechanistically remote from an NMDA receptor. We investigated whether add-on memantine reduced cytokine levels and benefitted patients w...
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Article
Open AccessA potential interaction between COMT and MTHFR genetic variants in Han Chinese patients with bipolar II disorder
Bipolar II disorder (BP-II), characterized by recurrent dysregulation of mood, is a serious and chronic psychiatric illness. However, BP-II is commonly under-recognized, even in psychiatric settings. Because d...
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Article
PET imaging of the brain serotonin transporters (SERT) with N,N-dimethyl-2-(2-amino-4-[18F]fluorophenylthio)benzylamine (4-[18F]-ADAM) in humans: a preliminary study
The aim of this study was to assess the feasibility of using 4-[18F]-ADAM as a brain SERT imaging agent in humans.
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Article
Erratum to: Inflammation in Patients with Schizophrenia: The Therapeutic Benefits of Risperidone Plus Add-On Dextromethorphan
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Article
Inflammation in Patients with Schizophrenia: The Therapeutic Benefits of Risperidone Plus Add-On Dextromethorphan
Increasing evidence suggests that inflammation contributes to the etiology and progression of schizophrenia. Molecules that initiate inflammation, such as virus- and toxin-induced cytokines, are implicated in ...
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Article
Open AccessInteraction between Serotonin Transporter and Serotonin Receptor 1 B genes polymorphisms may be associated with antisocial alcoholism
Several studies have hypothesized that genes regulating the components of the serotonin system, including serotonin transporter (5-HTTLPR) and serotonin 1 B receptor (5-HT1B), may be associated with alcoholism, b...
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Article
Simultaneous [99mTc]TRODAT-1 and [123I]ADAM Brain SPECT in Nonhuman Primates
This study examined the feasibility of simultaneous dopamine and serotonin transporter imaging using [123I]ADAM and [99mTc]TRODAT-1 single photon emission computed tomography (SPECT).
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Article
Neither single-marker nor haplotype analyses support an association between monoamine oxidase A gene and bipolar disorder
Monoamine oxidase A (MAOA) abnormality has been suggested as a crucial factor in the pathogenesis of mood disorder, because MAOA is associated with the metabolism of monoamines such as serotonin and norepineph...
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Chapter and Conference Paper
Fuzzy Similarity Measure and Fractional Image Query for Large Scale Protein 2D Gel Electrophoresis
Spot matching is a challenging problem in two dimensional protein gel electrophoresis (2DGE) chromatography images analysis. It is necessary to provide a robust solution to the problem of querying and matching...
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Article
Purification and Characterization of Porcine Testis 90-kDa Heat Shock Protein (HSP90) as a Substrate for Various Protein Kinases
We purified a large quantity of HSP90 from porcine testis by hydroxylapatite (HA-HSP90) and SDS-PAGE/electroelution (eluted-HSP90) to explore the molecular mechanism of HSP90 phosphorylation affecting its meta...
