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Article
Open AccessPhysical function as a predictor of chemotherapy-induced peripheral neuropathy in patients with pancreatic cancer
A growing body of research indicates that poor functional status before chemotherapy may be correlated with the severity of chemotherapy-induced peripheral neuropathy (CIPN) after the neurotoxic treatment. How...
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Article
Open AccessCorrection: Generational synaptic functions of GABAA receptor β3 subunit deteriorations in an animal model of social deficit
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Article
Open AccessAssociations of leptin and corticostriatal connectivity in bipolar disorder
Bipolar disorder (BD) and metabolic disturbance represent a chronic state of low-grade inflammation and corticostriatal circuitry alterations. Herein, we aimed to investigate whether plasma leptin, an adipokin...
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Article
Open AccessHigh-fat diet induces depression-like phenotype via astrocyte-mediated hyperactivation of ventral hippocampal glutamatergic afferents to the nucleus accumbens
Comorbidity exists between metabolic disorders and depressive syndrome with unclear mechanisms. To characterize the causal relationship, we adopted a 12-week high-fat diet (HFD) to induce metabolic disorder an...
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Article
Open AccessGenerational synaptic functions of GABAA receptor β3 subunit deteriorations in an animal model of social deficit
Disruption of normal brain development is implicated in numerous psychiatric disorders with neurodevelopmental origins, including autism spectrum disorder (ASD). Widespread abnormalities in brain structure and...
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Article
Open AccessCorrelation between loneliness, personality traits, and treatment outcomes in patients with methamphetamine use disorder
The aim of this study was to investigate whether loneliness and personality traits correlate with the treatment outcome of methamphetamine use disorder. In this 1-year longitudinal study, a total 106 participa...
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Article
Open AccessLoneliness and isolated living status in middle-aged and older adults in Taiwan: exploration on stress-related biomarkers, depressive symptoms, and disability
Loneliness is a subjective feeling by which an individual perceives a lack of closeness in interpersonal relationships. An isolated living status is linked with higher odds of risky health behavior. The confli...
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Article
Open AccessDevelopment and validation of a web-based prediction tool on minor physical anomalies for schizophrenia
In support of the neurodevelopmental model of schizophrenia, minor physical anomalies (MPAs) have been suggested as biomarkers and potential pathophysiological significance for schizophrenia. However, an integ...
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Article
Open AccessAssociation of visual motor processing and social cognition in schizophrenia
Patients with schizophrenia have difficulties in social cognitive domains including emotion recognition and mentalization, and in sensorimotor processing and learning. The relationship between social cognitive...
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Article
Heart Rate Variability with Deep Breathing in Drug-Naïve Patients with Schizophrenia
Abnormal autonomic nervous system (ANS) function may result in poor outcomes in patients with schizophrenia. Altered cardio-respiratory coupling, which indicates suppression of vagal activity, was identified a...
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Article
Open AccessDysregulation of oxytocin and dopamine in the corticostriatal circuitry in bipolar II disorder
The oxytocin (OXT) and dopamine systems synergistically facilitate striatal reactivity. Abnormal striatal activation has repeatedly been observed in patients with bipolar disorder (BD); however, such abnormali...
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Article
Open AccessIntermittent peripheral exposure to lipopolysaccharide induces exploratory behavior in mice and regulates brain glial activity in obese mice
Consecutive peripheral immune challenges can modulate the responses of brain resident microglia to stimuli. High-fat diet (HFD) intake has been reported to stimulate the activation of astrocytes and microglia ...
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Article
Open AccessCombination of dextromethorphan and memantine in treating bipolar spectrum disorder: a 12-week double-blind randomized clinical trial
The aim of this study is to determine whether adding combination of agents with anti-inflammatory and neurotrophic effects is more efficacious than mood stabilizer alone in improving clinical symptoms, plasma ...
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Article
Open AccessChronic exposure to high fat diet triggers myelin disruption and interleukin-33 upregulation in hypothalamus
Hypothalamic inflammation including astrogliosis and microglia activation occurs after intake of high fat diet (HFD) in rodent models or in obese individuals. However, the effect of chronic HFD feeding on olig...
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Article
Heart Rate Variability is Associated with Memory in Females
Research into the association between heart rate variability (HRV) and cognitive function is scarce, particularly with regard to gender differences. HRV in 182 healthy volunteers was assessed by the root mean ...
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Article
Open AccessEmotion-Specific Affective Theory of Mind Impairment in Parkinson’s Disease
The neuropathology of Parkinson’s disease (PD) involves the frontal-subcortical circuit, an area responsible for processing affective theory of mind (ToM). Patients with PD are expected to experience deficits ...
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Article
D-Cycloserine Ameliorates Autism-Like Deficits by Removing GluA2-Containing AMPA Receptors in a Valproic Acid-Induced Rat Model
Valproic acid (VPA)-exposed rat offspring have demonstrated autism spectrum disorder (ASD) phenotypes and impaired N-methyl-D-aspartate receptor (NMDAR)-dependent long-term depression (LTD) in the lateral nucl...
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Article
Open AccessPrefrontal cortex modulates the correlations between brain-derived neurotrophic factor level, serotonin, and the autonomic nervous system
Top-down regulation in the human brain and anatomical connections between the prefrontal cortex (PFC) and specific catecholamine-related regions have been well-studied. However, the way in which the PFC modula...
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Article
Alleviation of N-Methyl-d-Aspartate Receptor-Dependent Long-Term Depression via Regulation of the Glycogen Synthase Kinase-3β Pathway in the Amygdala of a Valproic Acid-Induced Animal Model of Autism
The amygdala plays crucial roles in socio-emotional behavior and cognition, both of which are abnormal in autism spectrum disorder (ASD). Valproic acid (VPA)-exposed rat offspring have demonstrated ASD phenoty...
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Article
Open AccessCorrection: Corrigendum: Low-dose add-on memantine treatment may improve cognitive performance and self-reported health conditions in opioid-dependent patients undergoing methadone-maintenance-therapy
Scientific Reports 5: Article number: 9708; published online: 19 May 2015; updated: 15 June 2017. In this Article, there are typographical errors in Table 2. The Continuous Performance Test (CPT) data for the ...
