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  1. No Access

    Article

    Co-aggregation of major psychiatric disorders in individuals with first-degree relatives with schizophrenia: a nationwide population-based study

    A previous genetic study has suggested that schizophrenia, bipolar disorder, major depressive disorder, autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) share common disease-a...

    C-M Cheng, W-H Chang, M-H Chen, C-F Tsai, T-P Su, C-T Li, S-J Tsai… in Molecular Psychiatry (2018)

  2. Article

    Open Access

    Erratum: The International SSRI Pharmacogenomics Consortium (ISPC): a genome-wide association study of antidepressant treatment response

    Correction to: Translational Psychiatry (2015) 5, e553; doi:10.1038/tp.2015.47; published online 21 April 2015 Following publication, the authors identified an error in the meta-analysis of ISPC, AMPS and STAR...

    J M Biernacka, K Sangkuhl, G Jenkins, R M Whaley, P Barman… in Translational Psychiatry (2016)

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  3. Article

    Open Access

    The International SSRI Pharmacogenomics Consortium (ISPC): a genome-wide association study of antidepressant treatment response

    Response to treatment with selective serotonin reuptake inhibitors (SSRIs) varies considerably between patients. The International SSRI Pharmacogenomics Consortium (ISPC) was formed with the primary goal of id...

    J M Biernacka, K Sangkuhl, G Jenkins, R M Whaley, P Barman… in Translational Psychiatry (2015)

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  4. No Access

    Article

    Gene–gene interactions of the INSIG1 and INSIG2 in metabolic syndrome in schizophrenic patients treated with atypical antipsychotics

    The use of atypical antipsychotics (AAPs) is associated with increasing the risk of the metabolic syndrome (MetS), which is an important risk factor for cardiovascular disease and diabetes. Two insulin-induced...

    Y-J Liou, Y M Bai, E Lin, J-Y Chen, T-T Chen, C-J Hong… in The Pharmacogenomics Journal (2012)

  5. No Access

    Article

    Glycogen synthase kinase-3β gene is associated with antidepressant treatment response in Chinese major depressive disorder

    Evidence suggests that glycogen synthase kinase-3β (GSK3B) activity is increased significantly in the brain of patients with major depressive disorders (MDD). Inhibition of GSK3B is thought to be a key feature...

    S-J Tsai, Y-J Liou, C-J Hong, Y W-Y Yu, T-J Chen in The Pharmacogenomics Journal (2008)

  6. No Access

    Article

    Response to fluoxetine and serotonin 1A receptor (C-1019G) polymorphism in Taiwan Chinese major depressive disorder

    Serotonin systems appear to play a key role in the pathogenesis of major depression and the therapeutic mechanisms of antidepressants. The firing rate of dorsal raphe serotonergic neurons is controlled by soma...

    C-J Hong, T-J Chen, Y W-Y Yu, S-J Tsai in The Pharmacogenomics Journal (2006)

  7. No Access

    Article

    Lack of association of catechol-O-methyltransferase gene Val108/158Met polymorphism with schizophrenia: a family-based association study in a Chinese population

    S-J Tsai, C-J Hong, S-J Hou, F-C Yen in Molecular Psychiatry (2006)

  8. No Access

    Article

    Association study of the serotonin transporter promoter polymorphism and symptomatology and antidepressant response in major depressive disorders

    The serotonin transporter (5-HTT) is the site of primary action for the selective serotonin reuptake inhibitors (SSRIs). Previous Western reports have demonstrated that the lallele of the 5-HTT gene-linked polymo...

    Y W-Y Yu, S-J Tsai, T-J Chen, C-H Lin, C-J Hong in Molecular Psychiatry (2002)