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Open AccessErratum: The International SSRI Pharmacogenomics Consortium (ISPC): a genome-wide association study of antidepressant treatment response
Correction to: Translational Psychiatry (2015) 5, e553; doi:10.1038/tp.2015.47; published online 21 April 2015 Following publication, the authors identified an error in the meta-analysis of ISPC, AMPS and STAR...
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Open AccessThe International SSRI Pharmacogenomics Consortium (ISPC): a genome-wide association study of antidepressant treatment response
Response to treatment with selective serotonin reuptake inhibitors (SSRIs) varies considerably between patients. The International SSRI Pharmacogenomics Consortium (ISPC) was formed with the primary goal of id...
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Article
Gene–gene interactions of the INSIG1 and INSIG2 in metabolic syndrome in schizophrenic patients treated with atypical antipsychotics
The use of atypical antipsychotics (AAPs) is associated with increasing the risk of the metabolic syndrome (MetS), which is an important risk factor for cardiovascular disease and diabetes. Two insulin-induced...
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Article
Glycogen synthase kinase-3β gene is associated with antidepressant treatment response in Chinese major depressive disorder
Evidence suggests that glycogen synthase kinase-3β (GSK3B) activity is increased significantly in the brain of patients with major depressive disorders (MDD). Inhibition of GSK3B is thought to be a key feature...
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Association study of polymorphisms in post-synaptic density protein 95 (PSD-95) with schizophrenia
The postsynaptic density protein 95 (PSD-95) – the prototype of this family – is a modular protein that enables anchoring of NMDA receptors, modulates NMDA receptor sensitivity to glutamate and coordinates NMD...
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Article
Association study of polymorphisms in glycine transporter with schizophrenia
Glycine acts as an obligatory co-agonist with glutamate on N-methyl-D-aspartate (NMDA) receptors. Brain glycine availability is determined by glycine transporters (GlyT1 or SLC6A9), which mediate glycine reuptake...
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Article
Response to fluoxetine and serotonin 1A receptor (C-1019G) polymorphism in Taiwan Chinese major depressive disorder
Serotonin systems appear to play a key role in the pathogenesis of major depression and the therapeutic mechanisms of antidepressants. The firing rate of dorsal raphe serotonergic neurons is controlled by soma...
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Lack of association of catechol-O-methyltransferase gene Val108/158Met polymorphism with schizophrenia: a family-based association study in a Chinese population
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Association studies of the adenosine A2a receptor (1976T > C) genetic polymorphism in Parkinson’s disease and schizophrenia
Given the implications with respect to the pathogenesis of dopaminergic dysfunction in schizophrenia and Parkinson’s disease (PD), as well as the reciprocal antagonistic interactions between adenosine A2a rece...
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Article
Association study of the dopamine and serotonin transporter genetic polymorphisms and methamphetamine abuse in Chinese males
The dopamine transporter (DAT) and the serotonin transporter (5-HTT) play important roles in methamphetamine (METH) dependence because they are the target of METH action. For this study, the association betwe...
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Association study of the serotonin transporter promoter polymorphism and symptomatology and antidepressant response in major depressive disorders
The serotonin transporter (5-HTT) is the site of primary action for the selective serotonin reuptake inhibitors (SSRIs). Previous Western reports have demonstrated that the lallele of the 5-HTT gene-linked polymo...
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Association study of Angiotensin I-converting enzyme polymorphism and symptomatology and antidepressant response in major depressive disorders
Angiotensin-converting enzyme (ACE) inhibitor has mood-elevating effects, and central ACE activity is increased for suicidal patients. In addition, substance P (SP), which is degraded by ACE, has been implica...
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Association analysis for genetic variants of the NMDA receptor 2b subunit (GRIN2B) and Parkinson's disease
Recent studies have implicated N-methyl-D-aspartate (NMDA) receptor dysfunction in the pathogenesis and treatment of Parkinson's disease (PD). The NMDA receptor is composed of several subunits, of which, the ...
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Article
A study of alpha-adrenoceptor gene polymorphisms and Alzheimer disease
There exists considerable evidence implicating abnormalities of the alpha (α)-adrenergic system in the development of Alzheimer disease (AD). We propose to investigate potential correlations between the prese...
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Article
Population of the excited Ne atoms in 3d levels by dissociative recombination in the neon afterglow plasmas at room temperature
The paper deals with the optical investigation of the dissociative recombination of Ne 2 + molecular ions with electrons in the afterglow period of d.c. and hi...