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Lack of association of catechol-O-methyltransferase gene Val108/158Met polymorphism with schizophrenia: a family-based association study in a Chinese population

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References

  1. Lewis CM et al. Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia. Am J Hum Genet 2003; 73: 34–48.

    Article  CAS  Google Scholar 

  2. Lotta T et al. Kinetics of human soluble and membrane-bound catechol O-methyltransferase: a revised mechanism and description of the thermolabile variant of the enzyme. Biochemistry 1995; 34: 4202–4210.

    Article  CAS  Google Scholar 

  3. Munafo MR et al. Lack of association of the COMT (Val(158/108) Met) gene and schizophrenia: a meta-analysis of case–control studies. Mol Psychiatry 2005; 10: 765–770.

    Article  CAS  Google Scholar 

  4. Glatt SJ et al. Association between a functional catechol O-methyltransferase gene polymorphism and schizophrenia: meta-analysis of case-control and family-based studies. Am J Psychiatry 2003; 160: 469–476.

    Article  Google Scholar 

  5. Li T et al. Preferential transmission of the high activity allele of COMT in schizophrenia. Psychiatr Genet 1996; 6: 131–133.

    Article  CAS  Google Scholar 

  6. Fan JB et al. Family-based association studies of COMT gene polymorphisms and schizophrenia in the Chinese population. Mol Psychiatry 2002; 7: 446–447.

    Article  CAS  Google Scholar 

  7. Tsai SJ et al. Association study of a functional catechol-O-methyltransferase genetic polymorphism with age of onset, cognitive function, symptomatology and prognosis in chronic schizophrenia. Neuropsychobiology 2004; 49: 196–200.

    Article  CAS  Google Scholar 

  8. Bray NJ et al. A haplotype implicated in schizophrenia susceptibility is associated with reduced COMT expression in human brain. Am J Hum Genet 2003; 73: 152–161.

    Article  CAS  Google Scholar 

  9. Zhu G et al. Differential expression of human COMT alleles in brain and lymphoblasts detected by RT-coupled 5′ nuclease assay. Psychopharmacology 2004; 177: 178–184.

    Article  CAS  Google Scholar 

  10. Shifman S et al. A highly significant association between a COMT haplotype and schizophrenia. Am J Hum Genet 2002; 71: 1296–1302.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

This work was supported by Grant CH-91-16 from the Cheng-Hsin Rehabilitation and Medical Center, and Grant VGH-90-238 from the Taipei Veterans General Hospital.

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Tsai, SJ., Hong, CJ., Hou, SJ. et al. Lack of association of catechol-O-methyltransferase gene Val108/158Met polymorphism with schizophrenia: a family-based association study in a Chinese population. Mol Psychiatry 11, 2–3 (2006). https://doi.org/10.1038/sj.mp.4001736

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