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  1. No Access

    Article

    Glycogen synthase kinase-3β gene is associated with antidepressant treatment response in Chinese major depressive disorder

    Evidence suggests that glycogen synthase kinase-3β (GSK3B) activity is increased significantly in the brain of patients with major depressive disorders (MDD). Inhibition of GSK3B is thought to be a key feature...

    S-J Tsai, Y-J Liou, C-J Hong, Y W-Y Yu, T-J Chen in The Pharmacogenomics Journal (2008)

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    Article

    Response to fluoxetine and serotonin 1A receptor (C-1019G) polymorphism in Taiwan Chinese major depressive disorder

    Serotonin systems appear to play a key role in the pathogenesis of major depression and the therapeutic mechanisms of antidepressants. The firing rate of dorsal raphe serotonergic neurons is controlled by soma...

    C-J Hong, T-J Chen, Y W-Y Yu, S-J Tsai in The Pharmacogenomics Journal (2006)

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    Article

    Association study of the serotonin transporter promoter polymorphism and symptomatology and antidepressant response in major depressive disorders

    The serotonin transporter (5-HTT) is the site of primary action for the selective serotonin reuptake inhibitors (SSRIs). Previous Western reports have demonstrated that the lallele of the 5-HTT gene-linked polymo...

    Y W-Y Yu, S-J Tsai, T-J Chen, C-H Lin, C-J Hong in Molecular Psychiatry (2002)