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Article
Open AccessTranscriptomic responses of Mediterranean sponges upon encounter with symbiont microbial consortia
Sponges (phylum Porifera) constantly interact with microbes. They graze on microbes from the water column by filter-feeding and they harbor symbiotic partners within their bodies. In experimental setups, spong...
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Article
Open AccessDiagnostic leukapheresis reveals distinct phenotypes of NSCLC circulating tumor cells
Circulating tumor cells (CTCs) hold immense promise for unraveling tumor heterogeneity and understanding treatment resistance. However, conventional methods, especially in cancers like non-small cell lung canc...
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Article
Open AccessNonlinear DNA methylation trajectories in aging male mice
Although DNA methylation data yields highly accurate age predictors, little is known about the dynamics of this quintessential epigenomic biomarker during lifespan. To narrow the gap, we investigate the methyl...
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Article
Open AccessEntorhinal cortex epigenome-wide association study highlights four novel loci showing differential methylation in Alzheimer’s disease
Studies on DNA methylation (DNAm) in Alzheimer’s disease (AD) have recently highlighted several genomic loci showing association with disease onset and progression.
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Article
Open AccessPersistent virus-specific and clonally expanded antibody-secreting cells respond to induced self-antigen in the CNS
B cells contribute to the pathogenesis of both cellular- and humoral-mediated central nervous system (CNS) inflammatory diseases through a variety of mechanisms. In such conditions, B cells may enter the CNS p...
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Article
Open AccessThe 3D enhancer network of the develo** T cell genome is shaped by SATB1
Mechanisms of tissue-specific gene expression regulation via 3D genome organization are poorly understood. Here we uncover the regulatory chromatin network of develo** T cells and identify SATB1, a tissue-sp...
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Article
Open AccessDifferential microRNA expression analyses across two brain regions in Alzheimer’s disease
Dysregulation of microRNAs (miRNAs) is involved in the pathogenesis of neurodegenerative diseases, including Alzheimer’s disease (AD). Hitherto, sample sizes from differential miRNA expression studies in AD ar...
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Article
Open AccessMicrobiota mediated plasticity promotes thermal adaptation in the sea anemone Nematostella vectensis
At the current rate of climate change, it is unlikely that multicellular organisms will be able to adapt to changing environmental conditions through genetic recombination and natural selection alone. Thus, it...
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Article
Open AccessUBTF::ATXN7L3 gene fusion defines novel B cell precursor ALL subtype with CDX2 expression and need for intensified treatment
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Article
Open AccessBottleneck size and selection level reproducibly impact evolution of antibiotic resistance
During antibiotic treatment, the evolution of bacterial pathogens is fundamentally affected by bottlenecks and varying selection levels imposed by the drugs. Bottlenecks—that is, reductions in bacterial popula...
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Article
Skin and gut imprinted helper T cell subsets exhibit distinct functional phenotypes in central nervous system autoimmunity
Multidimensional single-cell analyses of T cells have fueled the debate about whether there is extensive plasticity or ‘mixed’ priming of helper T cell subsets in vivo. Here, we developed an experimental frame...
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Article
Open AccessMulti-species transcriptome meta-analysis of the response to retinoic acid in vertebrates and comparative analysis of the effects of retinol and retinoic acid on gene expression in LMH cells
Retinol (RO) and its active metabolite retinoic acid (RA) are major regulators of gene expression in vertebrates and influence various processes like organ development, cell differentiation, and immune respons...
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Article
Sensitivity of Cercospora spp. from soybean to quinone outside inhibitors and methyl benzimidazole carbamate fungicides in Brazil
Cercospora leaf blight and purple seed stain are caused by Cercospora kikuchii and other Cercospora spp. The fungus can infect leaves and seeds on soybean, and the disease is controlled with fungicides. In Brazil...
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Article
Open AccessAnalysis of the brain transcriptome in lines of laying hens divergently selected for feather pecking
Feather pecking (FP) in laying hens reduces animal welfare and leads to economic losses for the layer industry. FP is considered a heritable condition that is influenced by dysregulation of neurotransmitter ho...
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Article
Somatic genetic drift and multilevel selection in a clonal seagrass
All multicellular organisms are genetic mosaics owing to somatic mutations. The accumulation of somatic genetic variation in clonal species undergoing asexual (or clonal) reproduction may lead to phenotypic he...
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Chapter and Conference Paper
Where Simplicity Meets Complexity: Hydra, a Model for Host–Microbe Interactions
For a long time, the main purpose of microbiology and immunology was to study pathogenic bacteria and infectious disease; the potential benefit of commensal bacteria remained unrecognised. Discovering that ind...
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Article
Das Prinzip Metaorganismus
Alle vielzelligen Organismen sind dauerhaft mit Mikroben assoziiert und daher Metaorganismen. Einfache Modellsysteme wie Hydra erlauben es, die evolutionäre Dynamik innerhalb eines solchen Metaorganismus zu an...
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Chapter
Hydra Go Bacterial
This chapter provides an overview of how the basal metazoan Hydra serves as model for untangling and dissecting the fundamental principles underlying complex host–microbe interactions.
