3 Result(s)

Article

IRF4 deficiency vulnerates B-cell progeny for leukemogenesis via somatically acquired Jak3 mutations conferring IL-7 hypersensitivity

The processes leading from disturbed B-cell development to adult B-cell progenitor acute lymphoblastic leukemia (BCP-ALL) remain poorly understood. Here, we describe Irf4^−/− mice as prone to develo** BCP-ALL wi...

Dennis Das Gupta, Christoph Paul, Nadine Samel… in Cell Death & Differentiation (2022)

Article

UBTF::ATXN7L3 gene fusion defines novel B cell precursor ALL subtype with CDX2 expression and need for intensified treatment

Lorenz Bastian, Alina M. Hartmann, Thomas Beder, Sonja Hänzelmann, Jan Kässens… in Leukemia (2022)

Protocol

Immunoglobulin/T-Cell Receptor Gene Rearrangement Analysis Using RNA-Seq

Identification of immunoglobulin (IG) and T-cell receptor (TR) gene rearrangements in acute lymphoblastic leukemia (ALL) patients at initial presentation are crucial for monitoring of minimal residual disease ...

Vincent H. J. van der Velden, Lorenz Bastian, Monika Brüggemann… in Immunogenetics (2022)