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  1. Article

    Open Access

    Integration of regulatory signals through involvement of multiple global regulators: control of the Escherichia coli gltBDF operon by Lrp, IHF, Crp, and ArgR

    The glutamate synthase operon (gltBDF) contributes to one of the two main pathways of ammonia assimilation in Escherichia coli. Of the seven most-global regulators, together affecting expression of about half of ...

    Ligi Paul, Pankaj K Mishra, Robert M Blumenthal, Rowena G Matthews in BMC Microbiology (2007)

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  2. No Access

    Article

    Effector regulation in a monomeric enzyme

    The monomeric B12-dependent ribonucleotide reductase from L. leichmannii has the central 10-stranded α/β-barrel found in all ribonucleotide reductases but incorporates two distinctive structural features, a novel...

    Martha L. Ludwig, Rowena G. Matthews in Nature Structural Biology (2002)

  3. No Access

    Article

    Domain alternation switches B12-dependent methionine synthase to the activation conformation

    B12-dependent methionine synthase (MetH) from Escherichia coli is a large modular protein that uses bound cobalamin as an intermediate methyl carrier. Major domain rearrangements have been postulated to explain h...

    Vahe Bandarian, Katherine A. Pattridge, Brett W. Lennon… in Nature Structural Biology (2002)

  4. No Access

    Chapter

    Making Methionine: A Love Affair with Folate

    I am deeply honored to be chosen as the Frederick Gowland Hopkins lecturer by my friends and colleagues. The honor is particularly special for me because my father traveled from New York to Cambridge to do his...

    Rowena G. Matthews in Chemistry and Biology of Pteridines and Folates (2002)

  5. No Access

    Article

    The structure and properties of methylenetetrahydrofolate reductase from Escherichia coli suggest how folate ameliorates human hyperhomocysteinemia

    Elevated plasma homocysteine levels are associated with increased risk for cardiovascular disease and neural tube defects in humans. Folate treatment decreases homocysteine levels and dramatically reduces the ...

    Brian D. Guenther, Christal A. Sheppard, Pamela Tran… in Nature Structural Biology (1999)

  6. No Access

    Chapter

    Interactions of adenosylmethionine with methylenetetrahydrofolate reductase

    Commercial preparations of AdoMet are isolated from yeast, and the AdoMet has the configuration of the natural diastereoisomer at both the sulfonium pole and the methionyl substituent. However, such preparatio...

    S Colette Creveling, Elisa C Krapf… in Biochemistry of S-Adenosylmethionine and R… (1982)