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  1. No Access

    Article

    Effector regulation in a monomeric enzyme

    The monomeric B12-dependent ribonucleotide reductase from L. leichmannii has the central 10-stranded α/β-barrel found in all ribonucleotide reductases but incorporates two distinctive structural features, a novel...

    Martha L. Ludwig, Rowena G. Matthews in Nature Structural Biology (2002)

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    Article

    Domain alternation switches B12-dependent methionine synthase to the activation conformation

    B12-dependent methionine synthase (MetH) from Escherichia coli is a large modular protein that uses bound cobalamin as an intermediate methyl carrier. Major domain rearrangements have been postulated to explain h...

    Vahe Bandarian, Katherine A. Pattridge, Brett W. Lennon… in Nature Structural Biology (2002)

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    Article

    The structure and properties of methylenetetrahydrofolate reductase from Escherichia coli suggest how folate ameliorates human hyperhomocysteinemia

    Elevated plasma homocysteine levels are associated with increased risk for cardiovascular disease and neural tube defects in humans. Folate treatment decreases homocysteine levels and dramatically reduces the ...

    Brian D. Guenther, Christal A. Sheppard, Pamela Tran… in Nature Structural Biology (1999)