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  1. No Access

    Article

    An informatic framework for decoding protein complexes by top-down mass spectrometry

    A computational approach for precisely identifying and characterizing the molecular stoichiometry of multi-proteoform complexes using native top-down mass spectrometry data is reported.

    Owen S Skinner, Pierre C Havugimana, Nicole A Haverland, Luca Fornelli… in Nature Methods (2016)

  2. No Access

    Article

    Radical SAM enzyme QueE defines a new minimal core fold and metal-dependent mechanism

    Crystal structures of QueE, a radical SAM enzyme that converts the purine base of GTP into a deazapurine found in natural products and tRNA, explain how the enzyme functions with a trimmed-down radical SAM enz...

    Daniel P Dowling, Nathan A Bruender, Anthony P Young… in Nature Chemical Biology (2014)

  3. No Access

    Article

    Delivery of tailor-made cobalamin to methylmalonyl-CoA mutase

    Methylmalonyl coenzyme A mutase (MCM) catalyzes the adenosylcobalamin-dependent isomerization of methylmalonyl-CoA to succinyl-CoA. Adenosyltransferase, an enzyme that carries out the final step in biosynthesi...

    Vahe Bandarian in Nature Chemical Biology (2008)

  4. No Access

    Article

    Domain alternation switches B12-dependent methionine synthase to the activation conformation

    B12-dependent methionine synthase (MetH) from Escherichia coli is a large modular protein that uses bound cobalamin as an intermediate methyl carrier. Major domain rearrangements have been postulated to explain h...

    Vahe Bandarian, Katherine A. Pattridge, Brett W. Lennon… in Nature Structural Biology (2002)