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    Article

    The structure and properties of methylenetetrahydrofolate reductase from Escherichia coli suggest how folate ameliorates human hyperhomocysteinemia

    Elevated plasma homocysteine levels are associated with increased risk for cardiovascular disease and neural tube defects in humans. Folate treatment decreases homocysteine levels and dramatically reduces the ...

    Brian D. Guenther, Christal A. Sheppard, Pamela Tran… in Nature Structural Biology (1999)

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    Chapter

    Methylenetetrahydrofolate Reductase: Comparison of the Enzyme from Mammalian and Bacterial Sources

    Methylenetetrahydrofolate reductase catalyzes the reduction of methylenetetrahydrofolate to methyl-tetrahydrofolate, which serves as the methyl donor for the conversion of homocysteine to methionine in the rea...

    Christal A. Sheppard, James S. Sumner… in Homocysteine Metabolism: From Basic Scienc… (1997)