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    Domain alternation switches B12-dependent methionine synthase to the activation conformation

    B12-dependent methionine synthase (MetH) from Escherichia coli is a large modular protein that uses bound cobalamin as an intermediate methyl carrier. Major domain rearrangements have been postulated to explain h...

    Vahe Bandarian, Katherine A. Pattridge, Brett W. Lennon in Nature Structural Biology (2002)