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Open AccessAuthor Correction: Genome-wide association study identifies Sjögren’s risk loci with functional implications in immune and glandular cells
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Article
Open AccessAuthor Correction: Genome-wide association study identifies Sjögren’s risk loci with functional implications in immune and glandular cells
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Article
Open AccessGenome-wide association study identifies Sjögren’s risk loci with functional implications in immune and glandular cells
Sjögren’s disease is a complex autoimmune disease with twelve established susceptibility loci. This genome-wide association study (GWAS) identifies ten novel genome-wide significant (GWS) regions in Sjögren’s ...
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Article
Open AccessImpaired activation of STAT5 upon IL-2 stimulation in Tregs and elevated sIL-2R in Sjögren’s syndrome
Interleukin-2 (IL-2) and the high-affinity IL-2 receptor (IL-2R) are essential for the survival of regulatory T cells (Tregs) which are the main players in immune tolerance and prevention of autoimmune disease...
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Article
3-Day monocyte-derived dendritic cells stimulated with a combination of OK432, TLR7/8 ligand, and prostaglandin E2 are a promising alternative for cancer immunotherapy
Numerous trials using dendritic cell (DC)-based vaccinations for the treatment of cancer are being carried out. However, an improvement of the quality of DC used is highly warranted. We here generated human mo...
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Article
Open AccessLong-term follow-up in primary Sjögren’s syndrome reveals differences in clinical presentation between female and male patients
Despite men being less prone to develop autoimmune diseases, male sex has been associated with a more severe disease course in several systemic autoimmune diseases. In the present study, we aimed to investigat...
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Article
Sjögren syndrome genetics vary according to ancestry
A pioneering new study scrutinising the genetic aetiology of Sjögren syndrome across different ancestries and clinical subtypes shows that the striking heterogeneity of associations observed in Sjögren syndrom...
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Article
Sjögren syndrome
Sjögren syndrome (SjS) is a systemic autoimmune disease that primarily affects the exocrine glands (mainly the salivary and lacrimal glands) and results in the severe dryness of mucosal surfaces, principally i...
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Article
Open AccessThe neutrophil protein S100A12 is associated with a comprehensive ultrasonographic synovitis score in a longitudinal study of patients with rheumatoid arthritis treated with adalimumab
The calcium-binding protein S100A12 correlates with measures of disease activity in patients with rheumatoid arthritis (RA). The protein reflects neutrophil activation and the present objective was to explore ...
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Article
Open AccessAltered phenotype and Stat1 expression in Toll-like receptor 7/8 stimulated monocyte-derived dendritic cells from patients with primary Sjögren’s syndrome
Dendritic cells (DC) are the most potent antigen-presenting cells of the immune system, involved in both initiating immune responses and maintaining tolerance. Dysfunctional and via toll-like receptor (TLR) li...
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Article
A possible genetic association with chronic fatigue in primary Sjögren’s syndrome: a candidate gene study
Fatigue is prevalent and disabling in primary Sjögren’s syndrome (pSS). Results from studies in chronic fatigue syndrome (CFS) indicate that genetic variation may influence fatigue. The aim of this study was t...
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Article
Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome
Kathy Sivils and colleagues report results of a large-scale association study of Sjögren's syndrome, a common autoimmune disease. They confirm strong associations with the HLA region and establish genome-wide ...
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Article
Open AccessTranscriptional landscapes of emerging autoimmunity: transient aberrations in the targeted tissue’s extracellular milieu precede immune responses in Sjögren’s syndrome
Our understanding of autoimmunity is skewed considerably towards the late stages of overt disease and chronic inflammation. Defining the targeted organ’s role during emergence of autoimmune diseases is, howeve...
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Article
Open AccessIn vitro suppression of immune responses using monocyte-derived tolerogenic dendritic cells from patients with primary Sjögren's syndrome
Therapeutic vaccination with antigen-specific tolerogenic dendritic cells (tolDC) might become a future option of individualized therapy for patients with autoimmune diseases. In this study, we tested the poss...
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Histopathology and Glandular Biopsies in Sjögren’s Syndrome
The glandular inflammatory lesion in Sjögren’s syndrome (SS) is a distinctive but not pathognomonic chronic lymphocytic adenitis best characterized in salivary glands. The glands are readily accessible; decrea...
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Etiology and Pathogenesis of Sjögren’s Syndrome with Special Emphasis on the Salivary Glands
Pathogenesis from the Greek pathos, “disease,” and genesis, “creation,” is the process by which an etiological factor and subsequent downstream events cause disease. Although in Sjögren’s syndrome (SS), alike ...
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Oral and Dental Manifestations of Sjögren’s Syndrome: Current Approaches to Diagnostics and Therapy
Saliva plays a detrimental role in oral health and disease. The quality and the quantity of saliva are determined by the glands it is secreted from, the sampling method, and whether secretion is stimulated or ...
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Article
Open AccessA five-year prospective study of fatigue in primary Sjögren's syndrome
Fatigue is prevalent in primary Sjögren's syndrome (pSS), and contributes to the considerably reduced health related quality of life in this disease. The symptom is included in proposed disease activity and ou...
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Article
Sjögren's syndrome: studying the disease in mice
Sjögren's syndrome (SS), a systemic autoimmune disease, is characterized by inflammation of exocrine tissues accompanied by a significant loss of their secretory function. Clinical symptoms develop late and th...
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Article
Open AccessSalivary glands of primary Sjögren's syndrome patients express factors vital for plasma cell survival
The presence of circulating Ro/SSA and La/SSB autoantibodies has become an important marker in the classification criteria for primary Sjögren's syndrome (pSS). Plasma cells producing these autoantibodies are ...
