-
Article
Open AccessAuthor Correction: Genome-wide association study identifies Sjögren’s risk loci with functional implications in immune and glandular cells
-
Article
Open AccessAuthor Correction: Genome-wide association study identifies Sjögren’s risk loci with functional implications in immune and glandular cells
-
Article
Implementing precision medicine in a regionally organized healthcare system in Sweden
-
Article
Open AccessGenome-wide association study identifies Sjögren’s risk loci with functional implications in immune and glandular cells
Sjögren’s disease is a complex autoimmune disease with twelve established susceptibility loci. This genome-wide association study (GWAS) identifies ten novel genome-wide significant (GWS) regions in Sjögren’s ...
-
Article
Open AccessVariants in BANK1 are associated with lupus nephritis of European ancestry
The genetic background of lupus nephritis (LN) has not been completely elucidated. We performed a case-only study of 2886 SLE patients, including 947 (33%) with LN. Renal biopsies were available from 396 patie...
-
Article
Open AccessSex differences in clinical presentation of systemic lupus erythematosus
Systemic lupus erythematosus (SLE) predominantly affects women, but previous studies suggest that men with SLE present a more severe disease phenotype. In this study, we investigated a large and well-character...
-
Article
Open AccessILF2 and ILF3 are autoantigens in canine systemic autoimmune disease
Dogs can spontaneously develop complex systemic autoimmune disorders, with similarities to human autoimmune disease. Autoantibodies directed at self-antigens are a key feature of these autoimmune diseases. Her...
-
Article
Open AccessLong-term follow-up in primary Sjögren’s syndrome reveals differences in clinical presentation between female and male patients
Despite men being less prone to develop autoimmune diseases, male sex has been associated with a more severe disease course in several systemic autoimmune diseases. In the present study, we aimed to investigat...
-
Article
Open AccessNovel risk genes for systemic lupus erythematosus predicted by random forest classification
Genome-wide association studies have identified risk loci for SLE, but a large proportion of the genetic contribution to SLE still remains unexplained. To detect novel risk genes, and to predict an individual’...
-
Article
A possible genetic association with chronic fatigue in primary Sjögren’s syndrome: a candidate gene study
Fatigue is prevalent and disabling in primary Sjögren’s syndrome (pSS). Results from studies in chronic fatigue syndrome (CFS) indicate that genetic variation may influence fatigue. The aim of this study was t...
-
Article
Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome
Kathy Sivils and colleagues report results of a large-scale association study of Sjögren's syndrome, a common autoimmune disease. They confirm strong associations with the HLA region and establish genome-wide ...
-
Article
Open AccessMutations in genes encoding complement inhibitors CD46 and CFHaffect the age at nephritis onset in patients with systemic lupus erythematosus
Inherited deficiencies of several complement components strongly predispose to systemic lupus erythematosus (SLE) while deficiencies of complement inhibitors are found in kidney diseases such as atypical hemol...
-
Article
A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus
Robert Graham and colleagues report results of a large-scale replication study for systemic lupus erythematosus (SLE) in individuals of European ancestry. Their findings expand the number of confirmed SLE susc...
-
Article
Mechanisms of Disease: primary Sjögren's syndrome and the type I interferon system
Despite extensive research, the etiopathogenesis of primary Sjögren's syndrome is not well understood. In this article, the hypothesis that activation of the type I interferon system contributes to the disease...
