33 Result(s)
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Richard L. Skolasky
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Article
Open AccessCharacterizing modifications to a comparative effectiveness research study: the OPTIMIZE trial—using the Framework for Reporting Adaptations and Modifications to Evidence-based Interventions (FRAME)
The OPTIMIZE trial is a multi-site, comparative effectiveness research (CER) study that uses a Sequential Multiple Assessment Randomized Trial (SMART) designed to examine the effectiveness of complex health in...
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Reference Work Entry In depth
Patient Activation: Utility in Elective Lumbar Spine Surgery
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Article
Preoperative duration of pain is associated with chronic opioid use after adult spinal deformity surgery
Few studies have explored the association between preoperative patient-reported measures and chronic opioid use following adult spinal deformity (ASD) surgery. We sought to explore the association between preo...
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Article
Open AccessListening to the elephant in the room: response-shift effects in clinical trials research
While a substantial body of work postulates that adaptation (response-shift effects) may serve to hide intervention benefits, much of the research was conducted in observational studies, not randomized-control...
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Article
If it’s information, it’s not “bias”: a sco** review and proposed nomenclature for future response-shift research
The growth in response-shift methods has enabled a stronger empirical foundation to investigate response-shift phenomena in quality-of-life (QOL) research; but many of these methods utilize certain language in...
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Article
Open AccessInitial presentation for acute low back pain: is early physical therapy associated with healthcare utilization and spending? A retrospective review of a National Database
Early initiation of physical therapy (PT) has been associated with lower healthcare costs and utilization; however, these studies have been limited to single institutions or healthcare systems. Our goal was to...
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Article
Transforming challenges into opportunities: conducting health preference research during the COVID-19 pandemic and beyond
The disruptions to health research during the COVID-19 pandemic are being recognized globally, and there is a growing need for understanding the pandemic’s impact on the health and health preferences of patien...
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Article
In Sync Working Group response-shift
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Article
Open AccessRole of psychosocial factors on the effect of physical activity on physical function in patients after lumbar spine surgery
The purpose of this study was to investigate the longitudinal postoperative relationship between physical activity, psychosocial factors, and physical function in patients undergoing lumbar spine surgery.
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Article
How is staging of ALIF following posterior spinal arthrodesis to the pelvis related to functional improvement in patients with adult spinal deformity?
Retrospective cohort.
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Article
Recurrence of proximal junctional kyphosis after revision surgery for symptomatic proximal junctional kyphosis in patients with adult spinal deformity: incidence, risk factors, and outcomes
Although proximal junctional kyphosis (PJK) is common after long spinal fusion, the outcomes of revision surgery for symptomatic PJK are unclear. Our aim was to assess the outcomes of revision surgery for symp...
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Article
Correction to: Opioid prescribing practices after posterior spinal arthrodesis for adolescent idiopathic scoliosis
The original version of this article unfortunately contained a mistake.
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Article
Opioid prescribing practices after posterior spinal arthrodesis for adolescent idiopathic scoliosis
Retrospective review.
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Article
Beta-amyloid (Aβ) uptake by PET imaging in older HIV+ and HIV- individuals
The causes of cognitive impairment among older HIV+ individuals may overlap with causes among elderly HIV seronegative (HIV-) individuals. The objective of this study was to determine if beta-amyloid (Aβ) depo...
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Article
Open AccessThe OPTIMIZE study: protocol of a pragmatic sequential multiple assessment randomized trial of nonpharmacologic treatment for chronic, nonspecific low back pain
Low back pain is a prevalent condition that causes a substantial health burden. Despite intensive and expensive clinical efforts, its prevalence is growing. Nonpharmacologic treatments are effective at improvi...
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Article
Clinical results and functional outcomes after three-column osteotomy at L5 or the sacrum in adult spinal deformity
Three-column osteotomies at L5 or the sacrum (LS3COs) are technically challenging, yet they may be needed to treat lumbosacral kyphotic deformities. We investigated radiographic and clinical outcomes after LS3CO.
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Article
Introduction to “Advancing quality‑of‑life research by deepening our understanding of response shift”
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Article
Open AccessSigma-1 Receptor Antagonist (BD1047) Decreases Cathepsin B Secretion in HIV-Infected Macrophages Exposed to Cocaine
Pathogenesis of HIV-associated neurocognitive disorders (HAND) is mediated through the infiltration of perivascular macrophages into the brain with the secretion of viral, neurotoxic and inflammatory proteins....
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Article
Paroxetine and fluconazole therapy for HIV-associated neurocognitive impairment: results from a double-blind, placebo-controlled trial
Paroxetine and fluconazole have neuroprotective effects in an in vitro model of HIV protein-mediated neuronal injury. This study evaluated the safety, tolerability, and efficacy of both paroxetine and fluconaz...
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Article
Soluble insulin receptor as a source of insulin resistance and cognitive impairment in HIV-seropositive women
Insulin resistance occurs in HIV-infected individuals and is associated with HIV-associated neurocognitive disorders (HAND). However, the mechanisms involved are not well understood. Previously, we showed a co...
