22 Result(s)

Article

Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways

Vascular endothelial growth factor (VEGF) upregulation is induced by many receptor and intracellular oncogenic proteins commonly activated in cancer, rendering molecular targeting of VEGF expression a complex ...

Qing Xu, Jon Briggs, Sungman Park, Guilian Niu, Marcin Kortylewski… in Oncogene (2005)

Article

Stat3 regulates genes common to both wound healing and cancer

Wound healing and cancer are both characterized by cell proliferation, remodeling of extracellular matrix, cell invasion and migration, new blood vessel formation, and modulation of blood coagulation. The mech...

Daniel J Dauer, Bernadette Ferraro, Lanxi Song, Bin Yu, Linda Mora… in Oncogene (2005)

Article

Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity

Constitutive activation of the JAK/STAT3 pathway is a major contributor to oncogenesis. In the present study, structure–activity relationship (SAR) studies with five cucurbitacin (Cuc) analogs, A, B, E, I, and...

Jiazhi Sun, Michelle A Blaskovich, Richard Jove, Sandra K Livingston… in Oncogene (2005)

Article

Cell-to-cell adhesion modulates Stat3 activity in normal and breast carcinoma cells

Stat3 (signal transducer and activator of transcription-3) activity is required for transformation by a number of oncogenes, while a constitutively active form of Stat3 alone is sufficient to induce neoplastic...

Adina Vultur, Jun Cao, Rozanne Arulanandam, James Turkson, Richard Jove… in Oncogene (2004)

Article

Activation of Stat3 by receptor tyrosine kinases and cytokines regulates survival in human non-small cell carcinoma cells

Overexpression of receptor tyrosine kinases including the epidermal growth factor receptor (EGF-R) as well as nonreceptor tyrosine kinases, such as Src, have been implicated in the formation of human lung canc...

Lanxi Song, James Turkson, James G Karras, Richard Jove, Eric B Haura in Oncogene (2003)

Chapter

STAT Proteins as Molecular Targets for Cancer Therapy

Constitutive activation of the STAT family members, Stat3 and Stat5, occurs at very high frequency in diverse human cancers. Persistent STAT signaling in tumor cells has been shown to increase the expression o...

Ralf Buettner, Marcin Kortylewski… in Signal Transducers and Activators of Trans… (2003)

Article

Inhibition of Bcr–Abl kinase activity by PD180970 blocks constitutive activation of Stat5 and growth of CML cells

Chronic myelogenous leukemia (CML) is a myeloproliferative disease characterized by the BCR–ABL genetic translocation and constitutive activation of the Abl tyrosine kinase. Among members of the Signal Transdu...

Mei Huang, Jay F Dorsey, PK Epling-Burnette, Ramadevi Nimmanapalli… in Oncogene (2002)

Article

Roles of activated Src and Stat3 signaling in melanoma tumor cell growth

Activation of protein tyrosine kinases is prevalent in human cancers and previous studies have demonstrated that Stat3 signaling is a point of convergence for many of these tyrosine kinases. Moreover, a critic...

Guilian Niu, Tammy Bowman, Mei Huang, Steve Shivers, Douglas Reintgen… in Oncogene (2002)

Article

Identification of Src transformation fingerprint in human colon cancer

We used a classical rodent model of transformation to understand the transcriptional processes, and hence the molecular and cellular events a given cell undergoes when progressing from a normal to a transforme...

Renae L Malek, Rosalyn B Irby, Qingbin M Guo, Kerry Lee, Sylvia Wong, Mei He… in Oncogene (2002)

Article

MEKK1-induced apoptosis requires TRAIL death receptor activation and is inhibited by AKT/PKB through inhibition of MEKK1 cleavage

MEK kinase 1 (MEKK1) induces apoptosis through the activation of caspases. The mechanism for MEKK1-induced apoptosis involves caspase-mediated cleavage of MEKK1, releasing a pro-apoptotic 91 kDa kinase fragmen...

Andrea H Bild, Francisco J Mendoza, Erika M Gibson, Mei Huang… in Oncogene (2002)

Article

Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis

Non-receptor and receptor tyrosine kinases, such as Src and EGF receptor (EGFR), are major inducers of vascular endothelial growth factor (VEGF), one of the most potent mediators of angiogenesis. While tyrosin...

Guilian Niu, Kenneth L Wright, Mei Huang, Lanxi Song, Eric Haura, James Turkson… in Oncogene (2002)

Article

Requirement of Stat3 signaling for HGF/SF-Met mediated tumorigenesis

Hepatocyte Growth Factor/Scatter Factor (HGF/SF) mediates a wide variety of cellular responses by acting through the Met tyrosine kinase receptor. Inappropriate expression of HGF/SF and/or Met has been found i...

Yu-Wen Zhang, Ling-Mei Wang, Richard Jove, George F Vande Woude in Oncogene (2002)

Article

Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells

Constitutive activation of signal transducer and activator of transcription (STAT) proteins has been detected in a wide variety of human primary tumor specimens and tumor cell lines including blood malignancie...

Roy Garcia, Tammy L Bowman, Guilian Niu, Hua Yu, Sue Minton… in Oncogene (2001)

Article

STAT proteins: novel molecular targets for cancer drug discovery

Signal Transducers and Activators of Transcription (STATs) are a family of cytoplasmic proteins with roles as signal messengers and transcription factors that participate in normal cellular responses to cytoki...

James Turkson, Richard Jove in Oncogene (2000)

Article

Induction of p21^WAF1/CIP1 and cyclin D1 expression by the Src oncoprotein in mouse fibroblasts: role of activated STAT3 signaling

While the activated viral Src oncoprotein, v-Src, induces uncontrolled cell growth, the mechanisms underlying cell cycle deregulation by v-Src have not been fully defined. Previous studies demonstrated that v-...

Dominic Sinibaldi, Walker Wharton, James Turkson, Tammy Bowman… in Oncogene (2000)

Article

Preface: STAT signaling

Richard Jove in Oncogene (2000)

Article

STATs in oncogenesis

Since their discovery as key mediators of cytokine signaling, considerable progress has been made in defining the structure-function relationships of Signal Transducers and Activators of Transcription (STATs)....

Tammy Bowman, Roy Garcia, James Turkson, Richard Jove in Oncogene (2000)

Article

Activation of Stat3 preassembled with platelet-derived growth factor β receptors requires Src kinase activity

Members of the STAT family of transcriptional regulators modulate the expression of a variety of gene products that promote cell proliferation, survival and transformation. Although initially identified as med...

Yi-Zhe Wang, Walker Wharton, Roy Garcia, Alan Kraker, Richard Jove, W J Pledger in Oncogene (2000)