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  1. Article

    Open Access

    31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one

    Andreas Lundqvist, Vincent van Hoef, **aonan Zhang… in Journal for ImmunoTherapy of Cancer (2016)

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  2. Article

    Open Access

    Phase II study of the farnesyltransferase inhibitor R115777 in advanced melanoma (CALGB 500104)

    Multiple farnesylated proteins are involved in signal transduction in cancer. Farnesyltransferase inhibitors (FTIs) have been developed as a strategy to inhibit the function of these proteins. As FTIs inhibit ...

    Thomas F Gajewski, April KS Salama, Donna Niedzwiecki… in Journal of Translational Medicine (2012)

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  3. No Access

    Article

    Tipifarnib-mediated suppression of T-bet-dependent signaling pathways

    Large granular lymphocyte (LGL) leukemia is a chronic lymphoproliferative disease in which T-bet [T-box transcription factor 21 gene (tbx21)] overexpression may play a pathogenic role. T-bet orchestrates the diff...

    Fanqi Bai, Alejandro V. Villagra, Jian**ang Zou… in Cancer Immunology, Immunotherapy (2012)

  4. No Access

    Article

    Inhibiting angiogenesis and tumorigenesis by a synthetic molecule that blocks binding of both VEGF and PDGF to their receptors

    Angiogenesis depends on vascular endothelial growth factor (VEGF) for initiation and platelet-derived growth factor (PDGF) for maintenance of blood vessels. We have designed a targeted library of compounds fro...

    Jiazhi Sun, De-an Wang, Rishi K Jain, Adam Carie, Steve Paquette, Eileen Ennis… in Oncogene (2005)

  5. No Access

    Article

    Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity

    Constitutive activation of the JAK/STAT3 pathway is a major contributor to oncogenesis. In the present study, structure–activity relationship (SAR) studies with five cucurbitacin (Cuc) analogs, A, B, E, I, and...

    Jiazhi Sun, Michelle A Blaskovich, Richard Jove, Sandra K Livingston… in Oncogene (2005)

  6. No Access

    Article

    Design of GFB-111, a platelet-derived growth factor binding molecule with antiangiogenic and anticancer activity against human tumors in mice

    We have designed a molecule, GFB-111, that binds to platelet-derived growth factor (PDGF), prevents it from binding to its receptor tyrosine kinase, and blocks PDGF-induced receptor autophosphorylation, activa...

    Michelle A. Blaskovich, Qing Lin, Frederic L. Delarue, Jiazhi Sun… in Nature Biotechnology (2000)