Skip to main content

6 Result(s)

within Jiazhi Sun Remove this filter

and

  1. Article

    Open Access

    The color change analysis of historic wooden remains after fire-suppression by fluorinated chemical gases

    Many wooden Chinese historic buildings are destroyed due to the ravages of frequent fire disasters. The fire risk of historic buildings are highly enlarged since a long-time weathered wooden structures in the ...

    Wei Ke, Wanyu Yang, Biao Zhou, Kai Wang, Jiazhi Sun, Xukun Sun, Min Xu… in Heritage Science (2021)

    Download PDF (2323 KB) View Article

  2. No Access

    Article

    Inhibiting angiogenesis and tumorigenesis by a synthetic molecule that blocks binding of both VEGF and PDGF to their receptors

    Angiogenesis depends on vascular endothelial growth factor (VEGF) for initiation and platelet-derived growth factor (PDGF) for maintenance of blood vessels. We have designed a targeted library of compounds fro...

    Jiazhi Sun, De-an Wang, Rishi K Jain, Adam Carie, Steve Paquette, Eileen Ennis… in Oncogene (2005)

  3. No Access

    Article

    Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity

    Constitutive activation of the JAK/STAT3 pathway is a major contributor to oncogenesis. In the present study, structure–activity relationship (SAR) studies with five cucurbitacin (Cuc) analogs, A, B, E, I, and...

    Jiazhi Sun, Michelle A Blaskovich, Richard Jove, Sandra K Livingston… in Oncogene (2005)

  4. No Access

    Article

    Inhibition of Angiogenesis by Aβ Peptides

    Aβ peptides are naturally occurring peptides forming β-sheet aggregates that constitute an integral component of senile plaques and vascular deposits in Alzheimer's disease. Since several peptides adopting a β-sh...

    Daniel Paris, Kirk Townsend, Amita Quadros, James Humphrey, Jiazhi Sun… in Angiogenesis (2004)

  5. No Access

    Article

    Design of GFB-111, a platelet-derived growth factor binding molecule with antiangiogenic and anticancer activity against human tumors in mice

    We have designed a molecule, GFB-111, that binds to platelet-derived growth factor (PDGF), prevents it from binding to its receptor tyrosine kinase, and blocks PDGF-induced receptor autophosphorylation, activa...

    Michelle A. Blaskovich, Qing Lin, Frederic L. Delarue, Jiazhi Sun… in Nature Biotechnology (2000)

  6. No Access

    Article

    Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts

    The ability of Ras oncoproteins to cause malignant transformation requires their post-translational modifications by prenyl groups. Because K-Ras can be both farnesylated and geranylgeranylated it is not known...

    Jiazhi Sun, Yimin Qian, Andrew D Hamilton, Saïd M Sebti in Oncogene (1998)