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Article
Open AccessActivated Src requires Cadherin-11, Rac, and gp130 for Stat3 activation and survival of mouse Balb/c3T3 fibroblasts
We previously demonstrated that engagement of cadherins, cell to cell adhesion molecules, triggers a dramatic increase in levels and activity of the Rac/Cdc42 small GTPases, which is followed by secretion of I...
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Article
Open AccessThe strategic combination of trastuzumab emtansine with oncolytic rhabdoviruses leads to therapeutic synergy
We have demonstrated that microtubule destabilizing agents (MDAs) can sensitize tumors to oncolytic vesicular stomatitis virus (VSVΔ51) in various preclinical models of cancer. The clinically approved T-DM1 (K...
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Article
Enhancement of oncolytic virotherapy by vanadium(V) dipicolinates
Oncolytic viruses rewire the immune system and can lead to long-lasting antitumor defenses against primary and metastatic tumors. However, results from clinical studies have shown heterogeneity in responses su...
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Article
Open AccessCombination of Paclitaxel and MG1 oncolytic virus as a successful strategy for breast cancer treatment
Breast cancer is the most common malignant disease amongst Western women. The lack of treatment options for patients with chemotherapy-resistant or recurrent cancers is pushing the field toward the rapid devel...
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Article
Reciprocal cellular cross-talk within the tumor microenvironment promotes oncolytic virus activity
John Bell and colleagues report that cross-talk between tumor and cancer-associated fibroblasts mediated by FGF2 can enhance efficacy of oncolytic virotherapy.
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Article
Microtubule disruption synergizes with oncolytic virotherapy by inhibiting interferon translation and potentiating bystander killing
In this study, we show that several microtubule-destabilizing agents used for decades for treatment of cancer and other diseases also sensitize cancer cells to oncolytic rhabdoviruses and improve therapeutic o...
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Article
Open AccessStat3 is a positive regulator of gap junctional intercellular communication in cultured, human lung carcinoma cells
Neoplastic transformation of cultured cells by a number of oncogenes such as src suppresses gap junctional, intercellular communication (GJIC); however, the role of Src and its effector Signal transducer and acti...
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Protocol
Electroporation of Adherent Cells In Situ for the Study of Signal Transduction and Gap Junctional Communication
Cultured adherent cells can be electroporated in situ, as they grow on a glass slide coated with electrically conductive, optically transparent indium-tin oxide (ITO). Although the introduction of DNA is a com...
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Article
Cell-to-cell adhesion modulates Stat3 activity in normal and breast carcinoma cells
Stat3 (signal transducer and activator of transcription-3) activity is required for transformation by a number of oncogenes, while a constitutively active form of Stat3 alone is sufficient to induce neoplastic...
