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  1. Article

    Open Access

    Tryptophan fuels MYC-dependent liver tumorigenesis through indole 3-pyruvate synthesis

    Cancer cells exhibit distinct metabolic activities and nutritional dependencies compared to normal cells. Thus, characterization of nutrient demands by individual tumor types may identify specific vulnerabilit...

    Niranjan Venkateswaran, Roy Garcia, M. Carmen Lafita-Navarro… in Nature Communications (2024)

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    Reference Work Entry In depth

    Signal Transducers and Activators of Transcription in Oncogenesis

    Ralf Buettner, Roy Garcia, Richard Jove in Encyclopedia of Cancer (2017)

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    Living Reference Work Entry In depth

    Signal Transducers and Activators of Transcription in Oncogenesis

    Ralf Buettner, Roy Garcia, Richard Jove in Encyclopedia of Cancer

  4. No Access

    Reference Work Entry In depth

    Signal Transducers and Activators of Transcription in Oncogenesis

    Ralf Buettner, Richard Jove, Roy Garcia in Encyclopedia of Cancer (2011)

  5. No Access

    Reference Work Entry In depth

    Signal Transducers and Activators of Transcription in Oncogenesis

    Ralf Buettner, Roy Garcia, Richard Jove in Encyclopedia of Cancer (2009)

  6. No Access

    Article

    Cutaneous Psammomatous Melanotic Schwannoma

    Background: Melanotic schwannoma is a pigmented nerve tumor that may be located in the skin and express local aggressivity. This tumor may occur singly. It may also be part of the Carney complex ...

    Nadine Claessens, Olivier Heymans… in American Journal of Clinical Dermatology (2003)

  7. No Access

    Article

    Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells

    Constitutive activation of signal transducer and activator of transcription (STAT) proteins has been detected in a wide variety of human primary tumor specimens and tumor cell lines including blood malignancie...

    Roy Garcia, Tammy L Bowman, Guilian Niu, Hua Yu, Sue Minton… in Oncogene (2001)

  8. Article

    Defining a molecular fingerprint of STAT3-regulated genes associated with oncogenesis using microarray technology and novel statistical methods

    Dominic Sinibaldi, Roy Garcia, Greg Bloom, Shrikant Mane, Peter Geiser… in Nature Genetics (2001)

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    Reference Work Entry In depth

    Signal Transducers and Activators of Transcription in Oncogenesis

    Roy Garcia, Richard Jove in Encyclopedic Reference of Cancer (2001)

  10. No Access

    Article

    STATs in oncogenesis

    Since their discovery as key mediators of cytokine signaling, considerable progress has been made in defining the structure-function relationships of Signal Transducers and Activators of Transcription (STATs)....

    Tammy Bowman, Roy Garcia, James Turkson, Richard Jove in Oncogene (2000)

  11. No Access

    Article

    Activation of Stat3 preassembled with platelet-derived growth factor β receptors requires Src kinase activity

    Members of the STAT family of transcriptional regulators modulate the expression of a variety of gene products that promote cell proliferation, survival and transformation. Although initially identified as med...

    Yi-Zhe Wang, Walker Wharton, Roy Garcia, Alan Kraker, Richard Jove, W J Pledger in Oncogene (2000)

  12. No Access

    Article

    Activation of STAT transcription factors in oncogenic tyrosine kinase signaling

    Signal transducers and activators of transcription (STATs) are cytoplasmic transcription factors that translocate to the nucleus and regulate gene expression in response to cytokine and growth factor stimulati...

    Roy Garcia, Dr. Richard Jove in Journal of Biomedical Science (1998)

  13. No Access

    Article

    Activation of c-Src by receptor tyrosine kinases in human colon cancer cells with high metastatic potential

    Recent data suggest that signal transduction may have a critical role in the development and regulation of the metastatic phenotype. Here, we investigated the role of c-Src activation in the process of human c...

    Weiguang Mao, Rosalyn Irby, Domenico Coppola, Ling Fu, Marek Wloch, Joel Turner… in Oncogene (1997)